Pathogenetic Mechanisms of Hepatitis C Virus-Induced B-Cell Lymphomagenesis
Joint Authors
Barozzi, Patrizia
Narni, Franco
Potenza, Leonardo
Maffei, Rossana
Forghieri, Fabio
Luppi, Mario
Marasca, Roberto
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hepatitis C virus (HCV) infection is probably the most common chronic viral infection and affects an estimated 180 million people worldwide, accounting for 3% of the global population.
Although the liver is considered to be the primary target, extrahepatic manifestations are well recognized among patients with chronic HCV infection.
Epidemiological studies have clearly demonstrated a correlation between chronic HCV infection and occurrence of B-cell non-Hodgkin's lymphomas (B-NHL).
The clinical evidence that antiviral therapy has a significant role in the treatment at least of some HCV-associated lymphoproliferative disorders, especially indolent B-NHL, further supports the existence of an etiopathogenetic link.
However, the mechanisms exploited by HCV to induce B-cell lymphoproliferation have so far not completely clarified.
It is conceivable that different biological mechanisms, namely, chronic antigen stimulation, high-affinity interaction between HCV-E2 protein and its cellular receptors, direct HCV infection of B-cells, and “hit and run” transforming events, may be combined themselves and cooperate in a multifactorial model of HCV-associated lymphomagenesis.
American Psychological Association (APA)
Forghieri, Fabio& Luppi, Mario& Barozzi, Patrizia& Maffei, Rossana& Potenza, Leonardo& Narni, Franco…[et al.]. 2012. Pathogenetic Mechanisms of Hepatitis C Virus-Induced B-Cell Lymphomagenesis. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-996831
Modern Language Association (MLA)
Forghieri, Fabio…[et al.]. Pathogenetic Mechanisms of Hepatitis C Virus-Induced B-Cell Lymphomagenesis. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-996831
American Medical Association (AMA)
Forghieri, Fabio& Luppi, Mario& Barozzi, Patrizia& Maffei, Rossana& Potenza, Leonardo& Narni, Franco…[et al.]. Pathogenetic Mechanisms of Hepatitis C Virus-Induced B-Cell Lymphomagenesis. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-996831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996831