Shining a Light on Intestinal Traffic
Joint Authors
Shanahan, Fergus
Melgar, Silvia
Nally, Kenneth
Murphy, Carola T.
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-22
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is associated with enhanced leukocyte infiltration to the gut, which is directly linked to the clinical aspects of these disorders.
Thus, leukocyte trafficking is a major target for IBD therapy.
Past and emerging techniques to study leukocyte trafficking both in vitro and in vivo have expanded our knowledge of the leukocyte migration process and the role of inhibitors.
Various strategies have been employed to target chemokine- and integrin-ligand interactions within the multistep adhesion cascade and the S1P/S1PR1 axis in leukocyte migration.
Though there is an abundance of preclinical data demonstrating efficacy of leukocyte trafficking inhibitors, many have yet to be confirmed in clinical studies.
Vigilance for toxicity and further research is required into this complex and emerging area of IBD therapy.
American Psychological Association (APA)
Murphy, Carola T.& Nally, Kenneth& Shanahan, Fergus& Melgar, Silvia. 2011. Shining a Light on Intestinal Traffic. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-996832
Modern Language Association (MLA)
Murphy, Carola T.…[et al.]. Shining a Light on Intestinal Traffic. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-996832
American Medical Association (AMA)
Murphy, Carola T.& Nally, Kenneth& Shanahan, Fergus& Melgar, Silvia. Shining a Light on Intestinal Traffic. Journal of Immunology Research. 2011. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-996832
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996832