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Novel Anti-Melanoma Immunotherapies: Disarming Tumor Escape Mechanisms
Joint Authors
Ben-Moshe, Tehila
Besser, Michal J.
Jacob, Schachter
Markel, Gal
Sivan, Sapoznik
Ortenberg, Rona
Hammer, Ohad
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The immune system fights cancer and sometimes temporarily eliminates it or reaches an equilibrium stage of tumor growth.
However, continuous immunological pressure also selects poorly immunogenic tumor variants that eventually escape the immune control system.
Here, we focus on metastatic melanoma, a highly immunogenic tumor, and on anti-melanoma immunotherapies, which recently, especially following the FDA approval of Ipilimumab, gained interest from drug development companies.
We describe new immunomodulatory approaches currently in the development pipeline, focus on the novel CEACAM1 immune checkpoint, and compare its potential to the extensively described targets, CTLA4 and PD1.
This paper combines multi-disciplinary approaches and describes anti-melanoma immunotherapies from molecular, medical, and business angles.
American Psychological Association (APA)
Sivan, Sapoznik& Hammer, Ohad& Ortenberg, Rona& Besser, Michal J.& Ben-Moshe, Tehila& Jacob, Schachter…[et al.]. 2012. Novel Anti-Melanoma Immunotherapies: Disarming Tumor Escape Mechanisms. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-996837
Modern Language Association (MLA)
Sivan, Sapoznik…[et al.]. Novel Anti-Melanoma Immunotherapies: Disarming Tumor Escape Mechanisms. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-996837
American Medical Association (AMA)
Sivan, Sapoznik& Hammer, Ohad& Ortenberg, Rona& Besser, Michal J.& Ben-Moshe, Tehila& Jacob, Schachter…[et al.]. Novel Anti-Melanoma Immunotherapies: Disarming Tumor Escape Mechanisms. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-996837
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996837