Mitochondrial Mutations are Associated with Atherosclerotic Lesions in the Human Aorta
Joint Authors
Sazonova, Margarita A.
Bobryshev, Yuri V.
Sobenin, Igor A.
Postnov, Anton Y.
Orekhov, Alexander N.
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Somatic mutations of the human mitochondrial genome can be a possible determinant of atherosclerosis.
To test this possibility, forty mitochondrial mutations were analyzed in the present study in order to see which of these mutations might be associated with atherosclerosis.
Ten mitochondrial mutations belonging to mitochondrial genes MT-RNR1 (rRNA 12S); MT-TL1 (tRNA-Leu, recognizes UUR); MT-TL2 (tRNA-Leu, recognizes CUN); MT-ND1, MT-ND2, MT-ND5, and MT-ND6 (subunits 1, 2, 5, and 6, respectively, of NADH dehydrogenase); and MT-CYB (cytochrome b) were potentially associated with atherosclerosis.
From 29% (2 of 7 aortic samples) upto 86% (6 of 7 aortic samples) of aortic samples had a significant difference between atherosclerotic plaques and unaffected tissue, with the respect to the level of heteroplasmy for each mutation.
Further, the homogenates of affected and normal intimae of 22 aortas were compared to reveal the average level of heteroplasmy for the above-mentioned 10 mutations.
For five mutations, the mean level of heteroplasmy was significantly different in atherosclerotic intimal homogenates in comparison with the unaffected tissue.
These mutations were A1555G, C3256T, T3336C, G13513A, and G15059A.
Thus, it was demonstrated that at least five mitochondrial mutations occurring in MT-RNR1, MT-TL1, MT-ND2, MT-ND5, and MT-CYB genes are associated with atherosclerosis.
American Psychological Association (APA)
Sobenin, Igor A.& Sazonova, Margarita A.& Postnov, Anton Y.& Bobryshev, Yuri V.& Orekhov, Alexander N.. 2012. Mitochondrial Mutations are Associated with Atherosclerotic Lesions in the Human Aorta. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-996863
Modern Language Association (MLA)
Sobenin, Igor A.…[et al.]. Mitochondrial Mutations are Associated with Atherosclerotic Lesions in the Human Aorta. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-996863
American Medical Association (AMA)
Sobenin, Igor A.& Sazonova, Margarita A.& Postnov, Anton Y.& Bobryshev, Yuri V.& Orekhov, Alexander N.. Mitochondrial Mutations are Associated with Atherosclerotic Lesions in the Human Aorta. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-996863
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996863