The Effects of TLR Activation on T-Cell Development and Differentiation
Joint Authors
Jin, Bo
Yang, Ying-Xiang
Yu, Xiao-Hong
Yeo, Anthony E. T.
Sun, Tao
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-32, 32 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-07
Country of Publication
Egypt
No. of Pages
32
Main Subjects
Abstract EN
Invading pathogens have unique molecular signatures that are recognized by Toll-like receptors (TLRs) resulting in either activation of antigen-presenting cells (APCs) and/or costimulation of T cells inducing both innate and adaptive immunity.
TLRs are also involved in T-cell development and can reprogram Treg cells to become helper cells.
T cells consist of various subsets, that is, Th1, Th2, Th17, T follicular helper (Tfh), cytotoxic T lymphocytes (CTLs), regulatory T cells (Treg) and these originate from thymic progenitor thymocytes.
T-cell receptor (TCR) activation in distinct T-cell subsets with different TLRs results in differing outcomes, for example, activation of TLR4 expressed in T cells promotes suppressive function of regulatory T cells (Treg), while activation of TLR6 expressed in T cells abrogates Treg function.
The current state of knowledge of regarding TLR-mediated T-cell development and differentiation is reviewed.
American Psychological Association (APA)
Jin, Bo& Sun, Tao& Yu, Xiao-Hong& Yang, Ying-Xiang& Yeo, Anthony E. T.. 2012. The Effects of TLR Activation on T-Cell Development and Differentiation. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-32.
https://search.emarefa.net/detail/BIM-996867
Modern Language Association (MLA)
Jin, Bo…[et al.]. The Effects of TLR Activation on T-Cell Development and Differentiation. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-32.
https://search.emarefa.net/detail/BIM-996867
American Medical Association (AMA)
Jin, Bo& Sun, Tao& Yu, Xiao-Hong& Yang, Ying-Xiang& Yeo, Anthony E. T.. The Effects of TLR Activation on T-Cell Development and Differentiation. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-32.
https://search.emarefa.net/detail/BIM-996867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996867