The Modulation of PPARγ1 and PPARγ2 mRNA Expression by Ciglitazone in CD3CD28-Activated Naïve and Memory CD4+ T Cells
Joint Authors
Nurul, Asma Abdullah
Mohamed, Rafeezul
Yaacob, Nik Soriani
Norazmi, Mohd. Nor
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Given their roles in immune regulation, the expression of the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) 1 and 2 isoforms was investigated in human naïve (CD45RA+) and memory (CD45RO+) CD4+ T cells.
Stimulation of both types of cells via the CD3/CD28 pathway resulted in high expression of both PPARγ receptors as measured by real-time PCR.
Treatment with the PPARγ agonist, ciglitazone, increased PPARγ1 expression but decreased PPARγ2 expression in stimulated naïve and memory cells.
Furthermore, when present, the magnitude of both PPARγ receptors expression was lower in naïve cells, perhaps suggesting a lower regulatory control of these cells.
Similar profiles of selected proinflammatory cytokines were expressed by the two cell types following stimulation.
The induction of PPARγ1 and suppression of PPARγ2 expressions in naïve and memory CD4+ T cells in the presence of ciglitazone suggest that the PPARγ subtypes may have different roles in the regulation of T-cell function.
American Psychological Association (APA)
Norazmi, Mohd. Nor& Mohamed, Rafeezul& Nurul, Asma Abdullah& Yaacob, Nik Soriani. 2012. The Modulation of PPARγ1 and PPARγ2 mRNA Expression by Ciglitazone in CD3CD28-Activated Naïve and Memory CD4+ T Cells. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-996888
Modern Language Association (MLA)
Norazmi, Mohd. Nor…[et al.]. The Modulation of PPARγ1 and PPARγ2 mRNA Expression by Ciglitazone in CD3CD28-Activated Naïve and Memory CD4+ T Cells. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-996888
American Medical Association (AMA)
Norazmi, Mohd. Nor& Mohamed, Rafeezul& Nurul, Asma Abdullah& Yaacob, Nik Soriani. The Modulation of PPARγ1 and PPARγ2 mRNA Expression by Ciglitazone in CD3CD28-Activated Naïve and Memory CD4+ T Cells. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-996888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996888