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Characterization of Chronic Cutaneous Lesions from TNF-Receptor-1-Deficient Mice Infected by Leishmania major
Joint Authors
Natale, Caio Cotta
Miranda, Luíza da Silva
Arantes, Rosa Maria Esteves
Santiago, Helton da Costa
Manzoni-de-Almeida, Daniel
Mello, Paula Seixas
Teixeira, Mauro Martins
Vieira, Leda Quercia
Ferraz, Fernanda Oliveira
dos Santos, Liliane Martins
Oliveira, Carolina Ferreira
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Leishmania major-infected TNF receptor 1 deficient (TNFR1 KO) mice resolve parasitism but fail to resolve lesions, while wild-type mice completely heal.
We investigated the cell composition, cytokine production, and apoptosis in lesions from L.
major-infected TNFR1 KO and wild-type (WT) mice.
Chronic lesions from L.
major-infected TNFR1 KO mice presented larger number of CD8+ T and Ly6G+ cells.
In addition, higher concentrations of mRNA for IFN-γ CCL2 and CCL5, as well as protein, but lower numbers of apoptotic cells, were found in lesions from TNFR1 KO mice than in WT, at late time points of infection.
Our studies showed that persistent lesions in L.
major-infected TNFR1 KO mice may be mediated by continuous migration of cells to the site of inflammation due to the presence of chemokines and also by lower levels of apoptosis.
We suggest that this model has some striking similarities to the mucocutaneous clinical form of leishmaniasis.
American Psychological Association (APA)
Oliveira, Carolina Ferreira& Manzoni-de-Almeida, Daniel& Mello, Paula Seixas& Natale, Caio Cotta& Santiago, Helton da Costa& Miranda, Luíza da Silva…[et al.]. 2011. Characterization of Chronic Cutaneous Lesions from TNF-Receptor-1-Deficient Mice Infected by Leishmania major. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-996899
Modern Language Association (MLA)
Oliveira, Carolina Ferreira…[et al.]. Characterization of Chronic Cutaneous Lesions from TNF-Receptor-1-Deficient Mice Infected by Leishmania major. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-996899
American Medical Association (AMA)
Oliveira, Carolina Ferreira& Manzoni-de-Almeida, Daniel& Mello, Paula Seixas& Natale, Caio Cotta& Santiago, Helton da Costa& Miranda, Luíza da Silva…[et al.]. Characterization of Chronic Cutaneous Lesions from TNF-Receptor-1-Deficient Mice Infected by Leishmania major. Journal of Immunology Research. 2011. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-996899
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996899