Association between Functional Polymorphisms of Foxp3 Gene and the Occurrence of Unexplained Recurrent Spontaneous Abortion in a Chinese Han Population
Joint Authors
Li, Zhuyu
Su, Xiumei
Zhang, Cai
Zhang, Xiuming
Wu, Zaigui
Li, Yinguang
You, Zeshan
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Unexplained recurrent spontaneous abortion (URSA) is an alloimmune disease associated with the failure of fetal-maternal immunologic tolerance in which the regulatory T lymphocytes (Treg) play a pivotal role.
It is well known that Forkhead box P3 (Foxp3) is a crucial regulatory factor for the development and function of Treg cells.
It has also been established that deficiency of the Foxp3 gene suppresses the regulatory function of Treg cells.
To determine if functional polymorphisms at the Foxp3 loci are associated with URSA in humans, we genotyped four common polymorphisms of Foxp3 gene in 146 unrelated URSA patients and 112 healthy women.
The results showed that rs3761548A/C and rs2232365A/G polymorphisms were significantly associated with URSA.
Additionally, we found that the allelic distribution of rs5902434 del/ATT in URSA group was slightly different from that in the control group.
We conclude that functional polymorphisms of the Foxp3 gene may confer an important susceptibility to URSA in the Chinese Han population, probably by altering Foxp3 function and/or its expression.
American Psychological Association (APA)
Wu, Zaigui& You, Zeshan& Zhang, Cai& Li, Zhuyu& Su, Xiumei& Zhang, Xiuming…[et al.]. 2011. Association between Functional Polymorphisms of Foxp3 Gene and the Occurrence of Unexplained Recurrent Spontaneous Abortion in a Chinese Han Population. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-996908
Modern Language Association (MLA)
Wu, Zaigui…[et al.]. Association between Functional Polymorphisms of Foxp3 Gene and the Occurrence of Unexplained Recurrent Spontaneous Abortion in a Chinese Han Population. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-996908
American Medical Association (AMA)
Wu, Zaigui& You, Zeshan& Zhang, Cai& Li, Zhuyu& Su, Xiumei& Zhang, Xiuming…[et al.]. Association between Functional Polymorphisms of Foxp3 Gene and the Occurrence of Unexplained Recurrent Spontaneous Abortion in a Chinese Han Population. Journal of Immunology Research. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-996908
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996908