Transcription Expression and Clinical Significance of Dishevelled-3 mRNA and δ-Catenin mRNA in Pleural Effusions from Patients with Lung Cancer
Joint Authors
Wang, En-Hua
Cha, Na
Zhao, Yu-Jie
Wu, Guang-Ping
Li, Wei-Nan
Li, Xiao-Yan
Wang, Shao-Cheng
Liu, Shu-Li
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
To evaluate diagnostic utility of Dishevelled-3 (DVL-3) mRNA and δ-catenin mRNA expression in pleural effusions of patients with lung cancer.
Methods.
DVL-3 mRNA and δ-catenin mRNA levels were assessed by performing RT-PCR on pleural effusion specimens from patients with lung cancer (n=75) and with lung benign disease (n=51).
Results.
The expressions of DVL-3 mRNA and δ-catenin mRNA were significantly higher in malignant than in benign lung disease (P<0.01) and were obviously higher than cytology in adenocarcinoma (P<0.01).
In single use, DVL-3 mRNA had the highest specificity (94.1%) and PPV (95.7%), whereas δ-catenin mRNA had the highest sensitivity (92.0%) and NPV (88.5%).
When combinations of markers were evaluated together, DVL-3 mRNA and δ-catenin mRNA gave a high-diagnostic performance: sensitivity of 100.0%, NPV of 100.0%, and accuracy of 96.0%, respectively.
Conclusion.
As molecular markers of detecting pleural micrometastasis, DVL-3 mRNA and δ-catenin mRNA are helpful to diagnose the cancer cells in pleural effusions of patients with lung cancer.
American Psychological Association (APA)
Li, Xiao-Yan& Liu, Shu-Li& Cha, Na& Zhao, Yu-Jie& Wang, Shao-Cheng& Li, Wei-Nan…[et al.]. 2012. Transcription Expression and Clinical Significance of Dishevelled-3 mRNA and δ-Catenin mRNA in Pleural Effusions from Patients with Lung Cancer. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-996909
Modern Language Association (MLA)
Li, Xiao-Yan…[et al.]. Transcription Expression and Clinical Significance of Dishevelled-3 mRNA and δ-Catenin mRNA in Pleural Effusions from Patients with Lung Cancer. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-996909
American Medical Association (AMA)
Li, Xiao-Yan& Liu, Shu-Li& Cha, Na& Zhao, Yu-Jie& Wang, Shao-Cheng& Li, Wei-Nan…[et al.]. Transcription Expression and Clinical Significance of Dishevelled-3 mRNA and δ-Catenin mRNA in Pleural Effusions from Patients with Lung Cancer. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-996909
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996909