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Regulatory T Cells in HIV Infection: Can Immunotherapy Regulate the Regulator?
Joint Authors
Routy, Jean-Pierre
Jenabian, Mohammad-Ali
Ancuta, Petronela
Gilmore, Norbert
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Regulatory T cells (Tregs) have a dominant role in self-tolerance and control of autoimmune diseases.
These cells also play a pivotal role in chronic viral infections and cancer by limiting immune activation and specific immune response.
The role of Tregs in HIV pathogenesis remains poorly understood as their function, changes according to the phases of infection.
Tregs can suppress anti-HIV specific responses and conversely can have a beneficial role by reducing the deleterious impact of immune activation.
We review the frequency, function and homing potential of Tregs in the blood and lymphoid tissues as well as their interaction with dendritic cells in the context of HIV infection.
We also examine the new insights generated by recombinant IL-2 and IL-7 clinical trials in HIV-infected adults, including the immunomodulatory effects of Tregs.
Based on their detrimental role in limiting anti-HIV responses, we propose Tregs as potential targets for immunotherapeutic strategies aimed at decreasing Tregs frequency and/or immunosuppressive function.
However, such approaches require a better understanding of the time upon infection when interfering with Treg function may not cause a deleterious state of hyperimmune activation.
American Psychological Association (APA)
Jenabian, Mohammad-Ali& Ancuta, Petronela& Gilmore, Norbert& Routy, Jean-Pierre. 2012. Regulatory T Cells in HIV Infection: Can Immunotherapy Regulate the Regulator?. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-996910
Modern Language Association (MLA)
Jenabian, Mohammad-Ali…[et al.]. Regulatory T Cells in HIV Infection: Can Immunotherapy Regulate the Regulator?. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-996910
American Medical Association (AMA)
Jenabian, Mohammad-Ali& Ancuta, Petronela& Gilmore, Norbert& Routy, Jean-Pierre. Regulatory T Cells in HIV Infection: Can Immunotherapy Regulate the Regulator?. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-996910
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996910