![](/images/graphics-bg.png)
New Roads Open Up for Implementing Immunotherapy in Mesothelioma
Joint Authors
Hegmans, Joost P. J. J.
Maat, A. P.
Hoogsteden, Henk C.
Heuvers, M. E.
Hendriks, Rudi W.
Cornelissen, R.
Aerts, Joachim G. J. V.
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-24
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Treatment options for malignant mesothelioma are limited, and the results with conventional therapies have been rather disappointing to this date.
Chemotherapy is the only evidence-based treatment for mesothelioma patients in good clinical condition, with an increase in median survival of only 2 months.
Therefore, there is urgent need for a different approach to battle this malignancy.
As chronic inflammation precedes mesothelioma, the immune system plays a key role in the initiation of this type of tumour.
Also, many immunological cell types can be found within the tumour at different stages of the disease.
However, mesothelioma cells can evade the surveillance capacity of the immune system.
They build a protective tumour microenvironment to harness themselves against the immune system's attacks, in which they even abuse immune cells to act against the antitumour immune response.
In our opinion, modulating the immune system simultaneously with the targeting of mesothelioma tumour cells might prove to be a superior treatment.
However, this strategy is challenging since the tumour microenvironment possesses numerous forms of defence strategies.
In this paper, we will discuss the interplay between immunological cells that can either inhibit or stimulate tumour growth and the challenges associated with immunotherapy.
We will provide possible strategies and discuss opportunities to overcome these problems.
American Psychological Association (APA)
Cornelissen, R.& Heuvers, M. E.& Maat, A. P.& Hendriks, Rudi W.& Hoogsteden, Henk C.& Aerts, Joachim G. J. V.…[et al.]. 2012. New Roads Open Up for Implementing Immunotherapy in Mesothelioma. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-996917
Modern Language Association (MLA)
Cornelissen, R.…[et al.]. New Roads Open Up for Implementing Immunotherapy in Mesothelioma. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-996917
American Medical Association (AMA)
Cornelissen, R.& Heuvers, M. E.& Maat, A. P.& Hendriks, Rudi W.& Hoogsteden, Henk C.& Aerts, Joachim G. J. V.…[et al.]. New Roads Open Up for Implementing Immunotherapy in Mesothelioma. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-996917
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996917