Exploiting the Interplay between Innate and Adaptive Immunity to Improve Immunotherapeutic Strategies for Epstein-Barr-Virus-Driven Disorders
Joint Authors
Merlo, Anna
Muraro, Elena
Rosato, Antonio
Martorelli, Debora
Turrini, Riccardo
Dolcetti, Riccardo
Faè, Damiana Antonia
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-29
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
The recent demonstration that immunotherapeutic approaches may be clinically effective for cancer patients has renewed the interest for this strategy of intervention.
In particular, clinical trials using adoptive T-cell therapies disclosed encouraging results, particularly in the context of Epstein-Barr-virus- (EBV-) related tumors.
Nevertheless, the rate of complete clinical responses is still limited, thus stimulating the development of more effective therapeutic protocols.
Considering the relevance of innate immunity in controlling both infections and cancers, innovative immunotherapeutic approaches should take into account also this compartment to improve clinical efficacy.
Evidence accumulated so far indicates that innate immunity effectors, particularly NK cells, can be exploited with therapeutic purposes and new targets have been recently identified.
We herein review the complex interactions between EBV and innate immunity and summarize the therapeutic strategies involving both adaptive and innate immune system, in the light of a fruitful integration between these immunotherapeutic modalities for a better control of EBV-driven tumors.
American Psychological Association (APA)
Martorelli, Debora& Muraro, Elena& Merlo, Anna& Turrini, Riccardo& Faè, Damiana Antonia& Rosato, Antonio…[et al.]. 2012. Exploiting the Interplay between Innate and Adaptive Immunity to Improve Immunotherapeutic Strategies for Epstein-Barr-Virus-Driven Disorders. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-996920
Modern Language Association (MLA)
Martorelli, Debora…[et al.]. Exploiting the Interplay between Innate and Adaptive Immunity to Improve Immunotherapeutic Strategies for Epstein-Barr-Virus-Driven Disorders. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-19.
https://search.emarefa.net/detail/BIM-996920
American Medical Association (AMA)
Martorelli, Debora& Muraro, Elena& Merlo, Anna& Turrini, Riccardo& Faè, Damiana Antonia& Rosato, Antonio…[et al.]. Exploiting the Interplay between Innate and Adaptive Immunity to Improve Immunotherapeutic Strategies for Epstein-Barr-Virus-Driven Disorders. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-996920
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996920