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Inaccuracy of Death Certificate Diagnosis of Tuberculosis and Potential Underdiagnosis of TB in a Region of High HIV Prevalence
Joint Authors
Liu, Theresa T.
Dawood, Halima
Alvarez, Gonzalo G.
Wilson, Douglas
Cameron, D. William
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Despite the South African antiretroviral therapy rollout, which should reduce the incidence of HIV-associated tuberculosis (TB), the number of TB-attributable deaths in KwaZuluNatal (KZN) remains high.
TB is often diagnosed clinically, without microbiologic confirmation, leading to inaccurate estimates of TB-attributed deaths.
This may contribute to avoidable deaths, and impact population-based TB mortality estimates.
Objectives.
(1) To measure the number of cases with microbiologically confirmed TB in a retrospective cohort of deceased inpatients with TB-attributed hospital deaths.
(2) To estimate the rates of multi-drug resistant (MDR) and extensively drug resistant (XDR) TB in this cohort.
Results.
Of 2752 deaths at EDH between September 2006 and March 2007, 403 (15%) were attributed to TB on the death certificate.
176 of the TB-attributed deaths (44%) had a specimen sent for smear or culture; only 64 (36%) had a TB diagnosis confirmed by either test.
Of the 39 culture-confirmed cases, 27/39 (69%) had fully susceptible TB and 27/39 (69%) had smear-negative culture-positive TB (SNTB).
Two patients had drug monoresistance, three patients had MDR-TB, and one had XDR-TB.
Conclusions.
Most TB-attributed deaths in this cohort were not microbiologically confirmed.
Of confirmed cases, most were smear-negative, culture positive and were susceptible to all first line drugs.
American Psychological Association (APA)
Liu, Theresa T.& Wilson, Douglas& Dawood, Halima& Cameron, D. William& Alvarez, Gonzalo G.. 2012. Inaccuracy of Death Certificate Diagnosis of Tuberculosis and Potential Underdiagnosis of TB in a Region of High HIV Prevalence. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-996924
Modern Language Association (MLA)
Liu, Theresa T.…[et al.]. Inaccuracy of Death Certificate Diagnosis of Tuberculosis and Potential Underdiagnosis of TB in a Region of High HIV Prevalence. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-996924
American Medical Association (AMA)
Liu, Theresa T.& Wilson, Douglas& Dawood, Halima& Cameron, D. William& Alvarez, Gonzalo G.. Inaccuracy of Death Certificate Diagnosis of Tuberculosis and Potential Underdiagnosis of TB in a Region of High HIV Prevalence. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-996924
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996924