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Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies
Joint Authors
Johnson, Theodore S.
Maria, Bernard L.
Munn, David H.
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-24
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Central nervous system tumors take advantage of the unique immunology of the CNS and develop exquisitely complex stromal networks that promote growth despite the presence of antigen-presenting cells and tumor-infiltrating lymphocytes.
It is precisely this immunological paradox that is essential to the survival of the tumor.
We review the evidence for functional CNS immune privilege and the impact it has on tumor tolerance.
In this paper, we place an emphasis on the role of tumor-infiltrating myeloid cells in maintaining stromal and vascular quiescence, and we underscore the importance of indoleamine 2,3-dioxygenase activity as a myeloid-driven tumor tolerance mechanism.
Much remains to be discovered regarding the tolerogenic mechanisms by which CNS tumors avoid immune clearance.
Thus, it is an open question whether tumor tolerance in the brain is fundamentally different from that of peripheral sites of tumorigenesis or whether it simply stands as a particularly strong example of such tolerance.
American Psychological Association (APA)
Johnson, Theodore S.& Munn, David H.& Maria, Bernard L.. 2012. Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-996925
Modern Language Association (MLA)
Johnson, Theodore S.…[et al.]. Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-996925
American Medical Association (AMA)
Johnson, Theodore S.& Munn, David H.& Maria, Bernard L.. Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-996925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996925