Immune-Regulatory Mechanisms in Systemic Autoimmune and Rheumatic Diseases
Joint Authors
Takakubo, Yuya
Konttinen, Yrjö T.
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Systemic autoimmune and rheumatic diseases (SAIRDs) are thought to develop due to the failure of autoimmune regulation and tolerance.
Current therapies, such as biologics, have improved the clinical results of SAIRDs; however, they are not curative treatments.
Recently, new discoveries have been made in immune tolerance and inflammation, such as tolerogenic dendritic cells, regulatory T and B cells, Th 17 cells, inflammatory and tolerogenic cytokines, and intracellular signaling pathways.
They lay the foundation for the next generation of the therapies beyond the currently used biologic therapies.
New drugs should target the core processes involved in disease mechanisms with the aim to attain complete cure combined with safety and low costs compared to the biologic agents.
Re-establishment of autoimmune regulation and tolerance in SAIRDs by the end of the current decade should be the final and realistic target.
American Psychological Association (APA)
Takakubo, Yuya& Konttinen, Yrjö T.. 2011. Immune-Regulatory Mechanisms in Systemic Autoimmune and Rheumatic Diseases. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-996927
Modern Language Association (MLA)
Takakubo, Yuya& Konttinen, Yrjö T.. Immune-Regulatory Mechanisms in Systemic Autoimmune and Rheumatic Diseases. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-996927
American Medical Association (AMA)
Takakubo, Yuya& Konttinen, Yrjö T.. Immune-Regulatory Mechanisms in Systemic Autoimmune and Rheumatic Diseases. Journal of Immunology Research. 2011. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-996927
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996927