Complement Diagnostics: Concepts, Indications, and Practical Guidelines

Joint Authors

Nilsson, Bo
Ekdahl, Kristina Nilsson

Source

Journal of Immunology Research

Issue

Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-11-14

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Biology

Abstract EN

Aberrations in the complement system have been shown to be direct or indirect pathophysiological mechanisms in a number of diseases and pathological conditions such as autoimmune disease, infections, cancer, allogeneic and xenogeneic transplantation, and inflammation.

Complement analyses have been performed on these conditions in both prospective and retrospective studies and significant differences have been found between groups of patients, but in many diseases, it has not been possible to make predictions for individual patients because of the lack of sensitivity and specificity of many of the assays used.

The basic indications for serological diagnostic complement analysis today may be divided into three major categories: (a) acquired and inherited complement deficiencies; (b) disorders with complement activation; (c) inherited and acquired C1INH deficiencies.

Here, we summarize indications, techniques, and interpretations for basic complement analyses and present an algorithm, which we follow in our routine laboratory.

American Psychological Association (APA)

Nilsson, Bo& Ekdahl, Kristina Nilsson. 2012. Complement Diagnostics: Concepts, Indications, and Practical Guidelines. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-996965

Modern Language Association (MLA)

Nilsson, Bo& Ekdahl, Kristina Nilsson. Complement Diagnostics: Concepts, Indications, and Practical Guidelines. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-996965

American Medical Association (AMA)

Nilsson, Bo& Ekdahl, Kristina Nilsson. Complement Diagnostics: Concepts, Indications, and Practical Guidelines. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-996965

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-996965