Complement Diagnostics: Concepts, Indications, and Practical Guidelines
Joint Authors
Nilsson, Bo
Ekdahl, Kristina Nilsson
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Aberrations in the complement system have been shown to be direct or indirect pathophysiological mechanisms in a number of diseases and pathological conditions such as autoimmune disease, infections, cancer, allogeneic and xenogeneic transplantation, and inflammation.
Complement analyses have been performed on these conditions in both prospective and retrospective studies and significant differences have been found between groups of patients, but in many diseases, it has not been possible to make predictions for individual patients because of the lack of sensitivity and specificity of many of the assays used.
The basic indications for serological diagnostic complement analysis today may be divided into three major categories: (a) acquired and inherited complement deficiencies; (b) disorders with complement activation; (c) inherited and acquired C1INH deficiencies.
Here, we summarize indications, techniques, and interpretations for basic complement analyses and present an algorithm, which we follow in our routine laboratory.
American Psychological Association (APA)
Nilsson, Bo& Ekdahl, Kristina Nilsson. 2012. Complement Diagnostics: Concepts, Indications, and Practical Guidelines. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-996965
Modern Language Association (MLA)
Nilsson, Bo& Ekdahl, Kristina Nilsson. Complement Diagnostics: Concepts, Indications, and Practical Guidelines. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-996965
American Medical Association (AMA)
Nilsson, Bo& Ekdahl, Kristina Nilsson. Complement Diagnostics: Concepts, Indications, and Practical Guidelines. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-996965
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996965