New Insight into Immunity and Immunopathology of Rickettsial Diseases
Joint Authors
Pepe, Ilenia
Carroccio, Antonio
di Rosa, Salvatore
Mansueto, Pasquale
Cascio, Antonio
Cillari, Enrico
Seidita, Aurelio
Walker, David H.
Vitale, Giustina
Rini, Giovam Battista
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-26, 26 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-05
Country of Publication
Egypt
No. of Pages
26
Main Subjects
Abstract EN
Human rickettsial diseases comprise a variety of clinical entities caused by microorganisms belonging to the genera Rickettsia, Orientia, Ehrlichia, and Anaplasma.
These microorganisms are characterized by a strictly intracellular location which has, for long, impaired their detailed study.
In this paper, the critical steps taken by these microorganisms to play their pathogenic roles are discussed in detail on the basis of recent advances in our understanding of molecular Rickettsia-host interactions, preferential target cells, virulence mechanisms, three-dimensional structures of bacteria effector proteins, upstream signalling pathways and signal transduction systems, and modulation of gene expression.
The roles of innate and adaptive immune responses are discussed, and potential new targets for therapies to block host-pathogen interactions and pathogen virulence mechanisms are considered.
American Psychological Association (APA)
Mansueto, Pasquale& Vitale, Giustina& Cascio, Antonio& Seidita, Aurelio& Pepe, Ilenia& Carroccio, Antonio…[et al.]. 2011. New Insight into Immunity and Immunopathology of Rickettsial Diseases. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-26.
https://search.emarefa.net/detail/BIM-996979
Modern Language Association (MLA)
Mansueto, Pasquale…[et al.]. New Insight into Immunity and Immunopathology of Rickettsial Diseases. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-26.
https://search.emarefa.net/detail/BIM-996979
American Medical Association (AMA)
Mansueto, Pasquale& Vitale, Giustina& Cascio, Antonio& Seidita, Aurelio& Pepe, Ilenia& Carroccio, Antonio…[et al.]. New Insight into Immunity and Immunopathology of Rickettsial Diseases. Journal of Immunology Research. 2011. Vol. 2012, no. 2012, pp.1-26.
https://search.emarefa.net/detail/BIM-996979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996979