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Cardiovascular Risk in Systemic Autoimmune Diseases: Epigenetic Mechanisms of Immune Regulatory Functions
Joint Authors
Pérez-Sánchez, Carlos
Rodriguez-Ariza, Antonio
Ramos-Casals, Manuel
López-Pedrera, Chary
Santos-Gonzalez, Monica
Cuadrado, Maria José
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Autoimmune diseases (AIDs) have been associated with accelerated atherosclerosis (AT) leading to increased cardio- and cerebrovascular disease risk.
Traditional risk factors, as well as systemic inflammation mediators, including cytokines, chemokines, proteases, autoantibodies, adhesion receptors, and others, have been implicated in the development of these vascular pathologies.
Yet, the characteristics of vasculopathies may significantly differ depending on the underlying disease.
In recent years, many new genes and signalling pathways involved in autoimmunity with often overlapping patterns between different disease entities have been further detected.
Epigenetics, the control of gene packaging and expression independent of alterations in the DNA sequence, is providing new directions linking genetics and environmental factors.
Epigenetic regulatory mechanisms comprise DNA methylation, histone modifications, and microRNA activity, all of which act upon gene and protein expression levels.
Recent findings have contributed to our understanding of how epigenetic modifications could influence AID development, not only showing differences between AID patients and healthy controls, but also showing how one disease differs from another and even how the expression of key proteins involved in the development of each disease is regulated.
American Psychological Association (APA)
López-Pedrera, Chary& Pérez-Sánchez, Carlos& Ramos-Casals, Manuel& Santos-Gonzalez, Monica& Rodriguez-Ariza, Antonio& Cuadrado, Maria José. 2011. Cardiovascular Risk in Systemic Autoimmune Diseases: Epigenetic Mechanisms of Immune Regulatory Functions. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-996984
Modern Language Association (MLA)
López-Pedrera, Chary…[et al.]. Cardiovascular Risk in Systemic Autoimmune Diseases: Epigenetic Mechanisms of Immune Regulatory Functions. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-996984
American Medical Association (AMA)
López-Pedrera, Chary& Pérez-Sánchez, Carlos& Ramos-Casals, Manuel& Santos-Gonzalez, Monica& Rodriguez-Ariza, Antonio& Cuadrado, Maria José. Cardiovascular Risk in Systemic Autoimmune Diseases: Epigenetic Mechanisms of Immune Regulatory Functions. Journal of Immunology Research. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-996984
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996984