Effect of Surface-Modified Paclitaxel Nanowires on U937 Cells In Vitro: A Novel Drug Delivery Vehicle
Joint Authors
Abumaree, Mohamed H.
Al-Suwaidan, Salem
Al-Kaysi, Rabih O.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We have fabricated surface-modified paclitaxel nanowires (SM-PNs) with a precise diameter and an average length of 50 μm.
The surface of these nanowires is coated with a monolayer of octadecylsiloxane (ODS), which prevents aggregation and enhances dispersivity in aqueous media.
This system constitutes a novel drug delivery vehicle based on one-dimensional (1D) nanostructures with a large drug to vehicle ratio.
We assayed the cytotoxicity of different diameter SM-PNs (200, 80, 35, and 18 nm) with U937 cells and compared their activity to microcrystalline paclitaxel.
SM-PNs reduced U937 cell proliferation in culture followed by cell death.
For the same amount of paclitaxel, different diameter SM-PNs displayed different cytotoxic effect at the same incubation time period.
SM-PNs with 35 nm diameters were the most efficient in completely halting cell proliferation following the first 24 hours of treatment, associated with 42% cell death.
SM-PNs with 18 nm diameters were least effective.
These SM-PNs can be tailored to fit a certain treatment protocol by simply choosing the appropriate diameter.
American Psychological Association (APA)
Abumaree, Mohamed H.& Al-Suwaidan, Salem& Al-Kaysi, Rabih O.. 2012. Effect of Surface-Modified Paclitaxel Nanowires on U937 Cells In Vitro: A Novel Drug Delivery Vehicle. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-997568
Modern Language Association (MLA)
Abumaree, Mohamed H.…[et al.]. Effect of Surface-Modified Paclitaxel Nanowires on U937 Cells In Vitro: A Novel Drug Delivery Vehicle. Journal of Nanomaterials No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-997568
American Medical Association (AMA)
Abumaree, Mohamed H.& Al-Suwaidan, Salem& Al-Kaysi, Rabih O.. Effect of Surface-Modified Paclitaxel Nanowires on U937 Cells In Vitro: A Novel Drug Delivery Vehicle. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-997568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-997568