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Pulmonary Toxicity, Distribution, and Clearance of Intratracheally Instilled Silicon Nanowires in Rats
Joint Authors
Roberts, Jenny R.
Mercer, Robert R.
Chapman, Rebecca S.
Cohen, Guy M.
Bangsaruntip, Sarunya
Schwegler-Berry, Diane
Scabilloni, James F.
Castranova, Vincent
Antonini, James M.
Leonard, Stephen S.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Silicon nanowires (Si NWs) are being manufactured for use as sensors and transistors for circuit applications.
The goal was to assess pulmonary toxicity and fate of Si NW using an in vivo experimental model.
Male Sprague-Dawley rats were intratracheally instilled with 10, 25, 50, 100, or 250 μg of Si NW (~20–30 nm diameter; ~2–15 μm length).
Lung damage and the pulmonary distribution and clearance of Si NW were assessed at 1, 3, 7, 28, and 91 days after-treatment.
Si NW treatment resulted in dose-dependent increases in lung injury and inflammation that resolved over time.
At day 91 after treatment with the highest doses, lung collagen was increased.
Approximately 70% of deposited Si NW was cleared by 28 days with most of the Si NW localized exclusively in macrophages.
In conclusion, Si NW induced transient lung toxicity which may be associated with an early rapid particle clearance; however, persistence of Si NW over time related to dose or wire length may lead to increased collagen deposition in the lung.
American Psychological Association (APA)
Roberts, Jenny R.& Mercer, Robert R.& Chapman, Rebecca S.& Cohen, Guy M.& Bangsaruntip, Sarunya& Schwegler-Berry, Diane…[et al.]. 2012. Pulmonary Toxicity, Distribution, and Clearance of Intratracheally Instilled Silicon Nanowires in Rats. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-997647
Modern Language Association (MLA)
Roberts, Jenny R.…[et al.]. Pulmonary Toxicity, Distribution, and Clearance of Intratracheally Instilled Silicon Nanowires in Rats. Journal of Nanomaterials No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-997647
American Medical Association (AMA)
Roberts, Jenny R.& Mercer, Robert R.& Chapman, Rebecca S.& Cohen, Guy M.& Bangsaruntip, Sarunya& Schwegler-Berry, Diane…[et al.]. Pulmonary Toxicity, Distribution, and Clearance of Intratracheally Instilled Silicon Nanowires in Rats. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-997647
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-997647