Hybrid Scaffolds for Tissue Regeneration: Chemotaxis and Physical Confinement as Sources of Biomimesis
Joint Authors
Sprio, Simone
Sandri, Monica
Panseri, Silvia
Cunha, Carla
Tampieri, Anna
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Biomineralization is a complex ensemble of concomitant phenomena, driving the development of vertebrate and invertebrate organisms, particularly the formation of human bone tissue.
In such a process collagen molecules assemble and organize in a complex 3-D structure and simultaneously mineralize with nearly amorphous apatite nanoparticles, whose heterogeneous nucleation, growth, and specific orientation are mediated by various chemical, physical, morphological, and structural control mechanisms, activated by the organic matrix at different size levels.
The present work investigates on in-lab biomineralization processes, performed to synthesize hybrid hydroxyapatite/collagen scaffolds for bone and osteochondral regeneration.
The synthesis processes are carried out by soft-chemistry procedures, with the purpose to activate all the different control mechanisms at the basis of new bone formation in vivo, so as to achieve scaffolds with high biomimesis, that is, physical, chemical, morphological, and ultrastructural properties very close to the newly formed human bone.
Deep analysis of cell behaviour in contact with such hybrid scaffolds confirms their strong affinity with human bone, which in turn determines high regenerative properties in vivo.
American Psychological Association (APA)
Sprio, Simone& Sandri, Monica& Panseri, Silvia& Cunha, Carla& Tampieri, Anna. 2012. Hybrid Scaffolds for Tissue Regeneration: Chemotaxis and Physical Confinement as Sources of Biomimesis. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-997678
Modern Language Association (MLA)
Sprio, Simone…[et al.]. Hybrid Scaffolds for Tissue Regeneration: Chemotaxis and Physical Confinement as Sources of Biomimesis. Journal of Nanomaterials No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-997678
American Medical Association (AMA)
Sprio, Simone& Sandri, Monica& Panseri, Silvia& Cunha, Carla& Tampieri, Anna. Hybrid Scaffolds for Tissue Regeneration: Chemotaxis and Physical Confinement as Sources of Biomimesis. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-997678
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-997678