Effect of Orally Administered Glutathione-Montmorillonite Hybrid Systems on Tissue Distribution
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
An ubiquitous tripeptide, glutathione (GSH), is assigned a role in detoxification, activation of immune system, intermediary metabolism, transport, and protection of cells against free radicals or reactive oxygen species.
However, instability of orally administered GSH in gastrointestinal (GI) tract leads to low absorption and low bioavailability in tissues.
In this study, we attempted to synthesize GSH-montmorillonite (MMT) hybrid systems by intercalating GSH into the interlayers of a cationic clay delivery carrier, MMT, to improve GSH bioavailability at the systemic level.
Polymer coating of the hybrid with polyvinylacetal diethylaminoacetate (AEA) was further performed to obtain better stability.
Synthetic condition of both GSH-MMT and AEA-GSH-MMT hybrids was optimized, and then GSH-delivery efficiency was evaluated in various organs after oral administration in normal as well as GSH-deficient mice.
The present GSH-MMT hybrids remarkably enhanced GSH concentration in the plasma, heart, kidney, and liver, especially when AEA-GSH-MMT hybrid was administered under GSH-deficient condition.
Moreover, both hybrids did not induce acute oral toxicity up to 2000 mg/kg, suggesting their great potential for pharmaceutical application.
American Psychological Association (APA)
Baek, Miri& Choi, Soo-Jin. 2012. Effect of Orally Administered Glutathione-Montmorillonite Hybrid Systems on Tissue Distribution. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-997755
Modern Language Association (MLA)
Baek, Miri& Choi, Soo-Jin. Effect of Orally Administered Glutathione-Montmorillonite Hybrid Systems on Tissue Distribution. Journal of Nanomaterials No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-997755
American Medical Association (AMA)
Baek, Miri& Choi, Soo-Jin. Effect of Orally Administered Glutathione-Montmorillonite Hybrid Systems on Tissue Distribution. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-997755
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-997755