Strategy for Designing Self-Assembling Peptides to Prepare Transparent Nanofiber Hydrogel at Neutral pH
Joint Authors
Yokoi, Hidenori
Kinoshita, Takatoshi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study examined the formation of nanofiber hydrogels at neutral pH for 16 types of peptides with different net charges, hydrophobicities, and degrees of polymerization.
The peptides formed various hydrogels depending on the arrangement of charged amino acids in the antiparallel β-sheet structure.
Circular dichroism (CD) measurement, atomic force microscopy (AFM), visible light spectroscopy, and dynamic viscoelasticity measurement showed that the formation of transparent nanofiber hydrogels in peptides requires at least 2 additional positively or negatively charged amino acids per peptide.
When designing the amino acid sequence, it is important to consider both the net charge and position of the charged amino acids, and it should be ensured that basic amino acids do not face other basic ones in the antiparallel β-sheet structure.
Peptides that had charged amino acids clustered at the center of the nanofiber formed rigid gels.
American Psychological Association (APA)
Yokoi, Hidenori& Kinoshita, Takatoshi. 2012. Strategy for Designing Self-Assembling Peptides to Prepare Transparent Nanofiber Hydrogel at Neutral pH. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-998214
Modern Language Association (MLA)
Yokoi, Hidenori& Kinoshita, Takatoshi. Strategy for Designing Self-Assembling Peptides to Prepare Transparent Nanofiber Hydrogel at Neutral pH. Journal of Nanomaterials No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-998214
American Medical Association (AMA)
Yokoi, Hidenori& Kinoshita, Takatoshi. Strategy for Designing Self-Assembling Peptides to Prepare Transparent Nanofiber Hydrogel at Neutral pH. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-998214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998214