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Gradient Technology for High-Throughput Screening of Interactions between Cells and Nanostructured Materials
Joint Authors
Michelmore, Andrew
Clements, Lauren
Steele, David A.
Voelcker, Nicolas H.
Szili, Endre J.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We present a novel substrate suitable for the high-throughput analysis of cell response to variations in surface chemistry and nanotopography.
Electrochemical etching was used to produce silicon wafers with nanopores between 10 and 100 nm in diameter.
Over this substrate and flat silicon wafers, a gradient film ranging from hydrocarbon to carboxylic acid plasma polymer was deposited, with the concentration of surface carboxylic acid groups varying between 0.7 and 3% as measured by XPS.
MG63 osteoblast-like cells were then cultured on these substrates and showed greatest cell spreading and adhesion onto porous silicon with a carboxylic acid group concentration between 2-3%.
This method has great potential for high-throughput screening of cell-material interaction with particular relevance to tissue engineering.
American Psychological Association (APA)
Michelmore, Andrew& Clements, Lauren& Steele, David A.& Voelcker, Nicolas H.& Szili, Endre J.. 2012. Gradient Technology for High-Throughput Screening of Interactions between Cells and Nanostructured Materials. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-998544
Modern Language Association (MLA)
Michelmore, Andrew…[et al.]. Gradient Technology for High-Throughput Screening of Interactions between Cells and Nanostructured Materials. Journal of Nanomaterials No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-998544
American Medical Association (AMA)
Michelmore, Andrew& Clements, Lauren& Steele, David A.& Voelcker, Nicolas H.& Szili, Endre J.. Gradient Technology for High-Throughput Screening of Interactions between Cells and Nanostructured Materials. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-998544
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998544