Evaluation of the Morphology and Osteogenic Potential ofTitania-Based Electrospun Nanofibers

Abstract EN

Submicron-scale titania-based ceramic fibers with various compositions have been prepared by electrospinning.

The as-prepared nanofibers were heat-treated at 700°C for 3 h to obtain pure inorganic fiber meshes.

The results show that the diameter and morphology of the nanofibers are affected by starting polymer concentration and sol-gel composition.

The titania and titania-silica nanofibers had the average diameter about 100–300 nm.

The crystal phase varied from high-crystallized rutile-anatase mixed crystal to low-crystallized anatase with adding the silica addition.

The morphology and crystal phase were evaluated by SEM and XRD.

Bone-marrow-derived mesenchymal stem cells were seeded on titania-silica 50/50 fiber meshes.

Cell number and early differentiation marker expressions were analyzed, and the results indicated osteogenic potential of the titania-silica 50/50 fiber meshes.