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Quantitative Evaluation of Acetaminophen in Oral Solutions by Dispersive Raman Spectroscopy for Quality Control
Joint Authors
Borio, Viviane G.
Vinha, Rubens
Nicolau, Renata A.
de Oliveira, Hueder Paulo M.
de Lima, Carlos J.
Silveira, Landulfo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-13
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
This work used dispersive Raman spectroscopy to evaluate acetaminophen in commercially available formulations as an analytical methodology for quality control in the pharmaceutical industry.
Raman spectra were collected using a near-infrared dispersive Raman spectrometer (830 nm, 50 mW, 20 s exposure time) coupled to a fiber optic probe.
Solutions of acetaminophen diluted in excipient (70 to 120% of the commercial concentration of 200 mg/mL) were used to develop a calibration model based on partial least squares (PLSs) applied to Raman spectra of solutions and, subsequently, obtain linearity, accuracy, precision (repeatability), and sensitivity of the method using the near-infrared spectroscopy (NIRS) as a gold standard method.
This model was used to predict the acetaminophen concentration in commercial samples from different lots of acetaminophen formulations (200 mg/mL) with a PLS-prediction error of about 0.6%.
Commercial medicines had PLS predicted concentrations errors below 2.5%, whereas NIRS had an error of about 3.7% compared to the label concentration.
It has been demonstrated the applicability of Raman spectroscopy with fiber probe for quality control in pharmaceutical industry of commercial formulations.
American Psychological Association (APA)
Borio, Viviane G.& Vinha, Rubens& Nicolau, Renata A.& de Oliveira, Hueder Paulo M.& de Lima, Carlos J.& Silveira, Landulfo. 2012. Quantitative Evaluation of Acetaminophen in Oral Solutions by Dispersive Raman Spectroscopy for Quality Control. Journal of Spectroscopy،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-998726
Modern Language Association (MLA)
Borio, Viviane G.…[et al.]. Quantitative Evaluation of Acetaminophen in Oral Solutions by Dispersive Raman Spectroscopy for Quality Control. Journal of Spectroscopy No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-998726
American Medical Association (AMA)
Borio, Viviane G.& Vinha, Rubens& Nicolau, Renata A.& de Oliveira, Hueder Paulo M.& de Lima, Carlos J.& Silveira, Landulfo. Quantitative Evaluation of Acetaminophen in Oral Solutions by Dispersive Raman Spectroscopy for Quality Control. Journal of Spectroscopy. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-998726
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998726