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Amyloid-Like Structures Formed by Azobenzene Peptides: Light-Triggered Disassembly
Joint Authors
Deeg, Andreas A.
Schrader, Tobias E.
Strzalka, Halina
Pfizer, Jose
Moroder, Luis
Zinth, Wolfgang
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The light-driven disassembly process of amyloid-like structures formed by azobenzene model peptides is studied by time-resolved mid-IR spectroscopy from nanoseconds to minutes.
The investigated peptide consists of two amino acid strands connected by the azobenzene switch.
The peptides aggregate to amyloid-like structures when the azobenzene chromophore is in the trans-conformation.
Illumination, resulting in a trans- to cis-isomerization of the azobenzene, leads to disaggregation of the aggregated structures.
After optical excitation and isomerization of the azobenzene, one finds absorption changes which recover to a large extent on the time scale of few nanoseconds.
These early absorption transients are assigned to the relaxation of vibrational excess energy (heat) or to structural rearrangements of isomerized azobenzene and the aggregated surroundings.
It is only on the time scale of minutes that spectral signatures appear which are characteristic for the disassembly of the aggregated structure.
American Psychological Association (APA)
Deeg, Andreas A.& Schrader, Tobias E.& Strzalka, Halina& Pfizer, Jose& Moroder, Luis& Zinth, Wolfgang. 2012. Amyloid-Like Structures Formed by Azobenzene Peptides: Light-Triggered Disassembly. Journal of Spectroscopy،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-998728
Modern Language Association (MLA)
Deeg, Andreas A.…[et al.]. Amyloid-Like Structures Formed by Azobenzene Peptides: Light-Triggered Disassembly. Journal of Spectroscopy No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-998728
American Medical Association (AMA)
Deeg, Andreas A.& Schrader, Tobias E.& Strzalka, Halina& Pfizer, Jose& Moroder, Luis& Zinth, Wolfgang. Amyloid-Like Structures Formed by Azobenzene Peptides: Light-Triggered Disassembly. Journal of Spectroscopy. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-998728
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998728