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Investigation of Preeclampsia Using Raman Spectroscopy
Joint Authors
Başar, Günay
Parlatan, Uğur
Şeninak, Şeyma
Günel, Tuba
Benian, Ali
Kalelioğlu, İbrahim
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-13
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Preeclampsia is associated with increased perinatal morbidity and mortality.
There have been numerous efforts to determine preeclampsia biomarkers by means of biophysical, biochemical, and spectroscopic methods.
In this study, the preeclampsia and control groups were compared via band component analysis and multivariate analysis using Raman spectroscopy as an alternative technique.
The Raman spectra of serum samples were taken from nine preeclamptic, ten healthy pregnant women.
The Band component analysis and principal component analysis-linear discriminant analysis were applied to all spectra after a sensitive preprocess step.
Using linear discriminant analysis, it was found that Raman spectroscopy has a sensitivity of 78% and a specificity of 90% for the diagnosis of preeclampsia.
Via the band component analysis, a significant difference in the spectra of preeclamptic patients was observed when compared to the control group.
19 Raman bands exhibited significant differences in intensity, while 11 of them decreased and eight of them increased.
This difference seen in vibrational bands may be used in further studies to clarify the pathophysiology of preeclampsia.
American Psychological Association (APA)
Başar, Günay& Parlatan, Uğur& Şeninak, Şeyma& Günel, Tuba& Benian, Ali& Kalelioğlu, İbrahim. 2012. Investigation of Preeclampsia Using Raman Spectroscopy. Journal of Spectroscopy،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-998749
Modern Language Association (MLA)
Başar, Günay…[et al.]. Investigation of Preeclampsia Using Raman Spectroscopy. Journal of Spectroscopy No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-998749
American Medical Association (AMA)
Başar, Günay& Parlatan, Uğur& Şeninak, Şeyma& Günel, Tuba& Benian, Ali& Kalelioğlu, İbrahim. Investigation of Preeclampsia Using Raman Spectroscopy. Journal of Spectroscopy. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-998749
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998749