The Role of Macrolides in Childhood Non-Cystic Fibrosis-Related Bronchiectasis
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Non-cystic fibrosis-related bronchiectasis is a chronic inflammatory lung disease, which is regarded as an “orphan” lung disease, with little research devoted to the study of this condition.
Bronchiectasis results in impaired quality of life and mortality if left untreated.
The tools available in the armamentarium for the management of bronchiectasis entail antibiotic therapy traditionally used to treat exacerbations, stratagems to improve mucociliary clearance, and avoidance of toxins.
Macrolides have been known for the last two decades to have not only anti-bacterial effects but immunomodulatory properties as well.
In cystic fibrosis, the use of macrolides is well documented in subjects colonized with Pseudomonas aeruginosa, to improve quality of life and lung function.
There is currently emerging evidence to suggest the benefit of macrolides in subjects not colonized with Pseudomonas aeruginosa.
This beneficial effect has been less explored in the context of bronchiectasis from other causes.
The purpose of this paper is to review the current literature on the use of macrolides in non-cystic fibrosis related bronchiectasis in paediatrics.
American Psychological Association (APA)
Masekela, R.& Green, R. J.. 2012. The Role of Macrolides in Childhood Non-Cystic Fibrosis-Related Bronchiectasis. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-998819
Modern Language Association (MLA)
Masekela, R.& Green, R. J.. The Role of Macrolides in Childhood Non-Cystic Fibrosis-Related Bronchiectasis. Mediators of Inflammation No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-998819
American Medical Association (AMA)
Masekela, R.& Green, R. J.. The Role of Macrolides in Childhood Non-Cystic Fibrosis-Related Bronchiectasis. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-998819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998819