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Zerumbone Attenuates the Severity of Acute Necrotizing Pancreatitis and Pancreatitis-Induced Hepatic Injury
Joint Authors
Wenhong, Deng
Jia, Yu
Weixing, Wang
Xiaoyan, Chen
Chen, Chen
Sheng, Xu
Hao, Jin
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This paper investigated the potential effects of zerumbone pretreatment on an acute necrotizing pancreatitis rat model induced by sodium taurocholate.
The pancreatitis injury was evaluated by serum AMY, sPLA2, and pancreatic pathological score.
Pancreatitis-induced hepatic injury was measured by ALT, AST, and hepatic histopathology.
The expression of I-κBα and NF-κB protein was evaluated by western blot and immunohistochemistry assay while ICAM-1 and IL-1β mRNA were examined by RT-PCR.
The results showed that AMY, sPLA2, ALT, and AST levels and histopathological assay of pancreatic and hepatic tissues were significantly reduced following administration of zerumbone.
Applying zerumbone also has been shown to inhibit NF-κB protein and downregulation of ICAM-1 and IL-1β mRNA.
The present paper suggests that treatment of zerumbone on rat attenuates the severity of acute necrotizing pancreatitis and pancreatitis-induced hepatic injury, via inhibiting NF-κB activation and downregulating the expression of ICAM-1 and IL-1β.
American Psychological Association (APA)
Wenhong, Deng& Jia, Yu& Weixing, Wang& Xiaoyan, Chen& Chen, Chen& Sheng, Xu…[et al.]. 2012. Zerumbone Attenuates the Severity of Acute Necrotizing Pancreatitis and Pancreatitis-Induced Hepatic Injury. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-998837
Modern Language Association (MLA)
Wenhong, Deng…[et al.]. Zerumbone Attenuates the Severity of Acute Necrotizing Pancreatitis and Pancreatitis-Induced Hepatic Injury. Mediators of Inflammation No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-998837
American Medical Association (AMA)
Wenhong, Deng& Jia, Yu& Weixing, Wang& Xiaoyan, Chen& Chen, Chen& Sheng, Xu…[et al.]. Zerumbone Attenuates the Severity of Acute Necrotizing Pancreatitis and Pancreatitis-Induced Hepatic Injury. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-998837
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998837