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Inhibition of Osteoclast Generation: A Novel Function of the Bone Morphogenetic Protein 7Osteogenic Protein 1
Joint Authors
Wagner, Christof
Maurer, Thomas
Zimmermann, Gerald
Maurer, Susanne
Stegmaier, Sabine
Hänsch, Gertrud Maria
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Monocytes have the potential to differentiate to either macrophages, dendritic cells, or to osteoclasts.
The microenvironment, particularly cytokines, directs the monocyte differentiation.
Receptors of NFκB (RANK) ligand, tumor necrosis factor (TNF) α, or interleukin- (IL-) 8 have be identified as inducers of osteoclastogenesis, whereas others, such as IL-10 or transforming growth factor (TGF)ß inhibit osteoclast generation or induce differentiation towards a dendritic cell type.
We now describe that bone morphogenetic protein (BMP) 7/osteogenic protein- (OP-) 1 inhibited the differentiation of human CD14+ monocytes to osteoclasts.
In the presence of BMP7/OP-1 the transcription factors c-Fos and NFATc1, though upregulated and translocated to the nucleus in response to either RANKL or IL-8, did not persist.
In parallel, MafB, a transcription factor expressed by monocytes and required for differentiation to macrophages but inhibiting osteoclast generation, was preserved.
Because both persistence of NFATc1 and downregulation of MafB are crucial for osteoclastogenesis, we conclude that BMP7/OP-1 inhibits the generation of osteoclasts by interfering with signalling pathways.
American Psychological Association (APA)
Maurer, Thomas& Zimmermann, Gerald& Maurer, Susanne& Stegmaier, Sabine& Wagner, Christof& Hänsch, Gertrud Maria. 2012. Inhibition of Osteoclast Generation: A Novel Function of the Bone Morphogenetic Protein 7Osteogenic Protein 1. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-998843
Modern Language Association (MLA)
Maurer, Thomas…[et al.]. Inhibition of Osteoclast Generation: A Novel Function of the Bone Morphogenetic Protein 7Osteogenic Protein 1. Mediators of Inflammation No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-998843
American Medical Association (AMA)
Maurer, Thomas& Zimmermann, Gerald& Maurer, Susanne& Stegmaier, Sabine& Wagner, Christof& Hänsch, Gertrud Maria. Inhibition of Osteoclast Generation: A Novel Function of the Bone Morphogenetic Protein 7Osteogenic Protein 1. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-998843
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998843