Possible Roles of Proinflammatory and Chemoattractive Cytokines Produced by Human Fetal Membrane Cells in the Pathology of Adverse Pregnancy Outcomes Associated with Influenza Virus Infection
Joint Authors
Uchide, Noboru
Ohyama, Kunio
Bessho, Toshio
Takeichi, Makoto
Toyoda, Hiroo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-32, 32 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-31
Country of Publication
Egypt
No. of Pages
32
Main Subjects
Abstract EN
Pregnant women are at an increased risk of influenza-associated adverse outcomes, such as premature delivery, based on data from the latest pandemic with a novel influenza A (H1N1) virus in 2009-2010.
It has been suggested that the transplacental transmission of influenza viruses is rarely detected in humans.
A series of our study has demonstrated that influenza virus infection induced apoptosis in primary cultured human fetal membrane chorion cells, from which a factor with monocyte differentiation-inducing (MDI) activity was secreted.
Proinflammatory cytokines, such as interleukin (IL)-6, tumor necrosis factor (TNF)-α, and interferon (IFN)-β, were identified as a member of the MDI factor.
Influenza virus infection induced the mRNA expression of not only the proinflammatory cytokines but also chemoattractive cytokines, such as monocyte chemoattractant protein (MCP)-1, regulated on activation, normal T-cell expressed and secreted (RANTES), macrophage inflammatory protein (MIP)-1β, IL-8, growth-regulated oncogene (GRO)-α, GRO-β, epithelial cell-derived neutrophil-activating protein (ENA)-78, and interferon inducible protein (IP)-10 in cultured chorion cells.
These cytokines are postulated to associate with human parturition.
This paper, therefore, reviews (1) lessons from pandemic H1N1 2009 in pregnancy, (2) production of proinflammatory and chemoattractive cytokines by human fetal membranes and their functions in gestational tissues, and (3) possible roles of cytokines produced by human fetal membranes in the pathology of adverse pregnancy outcomes associated with influenza virus infection.
American Psychological Association (APA)
Uchide, Noboru& Ohyama, Kunio& Bessho, Toshio& Takeichi, Makoto& Toyoda, Hiroo. 2012. Possible Roles of Proinflammatory and Chemoattractive Cytokines Produced by Human Fetal Membrane Cells in the Pathology of Adverse Pregnancy Outcomes Associated with Influenza Virus Infection. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-32.
https://search.emarefa.net/detail/BIM-998866
Modern Language Association (MLA)
Uchide, Noboru…[et al.]. Possible Roles of Proinflammatory and Chemoattractive Cytokines Produced by Human Fetal Membrane Cells in the Pathology of Adverse Pregnancy Outcomes Associated with Influenza Virus Infection. Mediators of Inflammation No. 2012 (2012), pp.1-32.
https://search.emarefa.net/detail/BIM-998866
American Medical Association (AMA)
Uchide, Noboru& Ohyama, Kunio& Bessho, Toshio& Takeichi, Makoto& Toyoda, Hiroo. Possible Roles of Proinflammatory and Chemoattractive Cytokines Produced by Human Fetal Membrane Cells in the Pathology of Adverse Pregnancy Outcomes Associated with Influenza Virus Infection. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-32.
https://search.emarefa.net/detail/BIM-998866
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998866