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Essential Role of Mast Cells in the Visceral Hyperalgesia Induced by T. spiralis Infection and Stress in Rats
Joint Authors
Yang, Chang-Qing
Wei, Yan-Yu
Zhong, Chan-Juan
Duan, Li-Ping
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mast cells (MCs) deficient rats (Ws/Ws) were used to investigate the roles of MCs in visceral hyperalgesia.
Ws/Ws and wild control (+/+) rats were exposed to T.
spiralis or submitted to acute cold restraint stress (ACRS).
Levels of proteinase-activated receptor 2 (PAR2) and nerve growth factor (NGF) were determined by immunoblots and RT-PCR analysis, and the putative signal pathways including phosphorylated extracellular-regulated kinase (pERK1/2) and transient receptor potential vanilloid receptor 1 (TRPV1) were further identified.
Visceral hyperalgesia triggered by ACRS was observed only in +/+ rats.
The increased expression of PAR2 and NGF was observed only in +/+ rats induced by T.
spiralis and ACRS.
The activation of pERK1/2 induced by ACRS occurred only in +/+ rats.
However, a significant increase of TRPV1 induced by T.
spiralis and ACRS was observed only in +/+ rats.
The activation of PAR2 and NGF via both TRPV1 and pERK1/2 signal pathway is dependent on MCs in ACRS-induced visceral hyperalgesia rats.
American Psychological Association (APA)
Yang, Chang-Qing& Wei, Yan-Yu& Zhong, Chan-Juan& Duan, Li-Ping. 2012. Essential Role of Mast Cells in the Visceral Hyperalgesia Induced by T. spiralis Infection and Stress in Rats. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-998869
Modern Language Association (MLA)
Yang, Chang-Qing…[et al.]. Essential Role of Mast Cells in the Visceral Hyperalgesia Induced by T. spiralis Infection and Stress in Rats. Mediators of Inflammation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-998869
American Medical Association (AMA)
Yang, Chang-Qing& Wei, Yan-Yu& Zhong, Chan-Juan& Duan, Li-Ping. Essential Role of Mast Cells in the Visceral Hyperalgesia Induced by T. spiralis Infection and Stress in Rats. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-998869
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998869