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Cytokines in Pericardial Effusion of Patients with Inflammatory Pericardial Disease
Joint Authors
Karatolios, Konstantinos
Moosdorf, Rainer
Maisch, Bernhard
Pankuweit, Sabine
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The role of inflammatory and angiogenic cytokines in patients with inflammatory pericardial effusion still remains uncertain.
Methods.
We assessed pericardial and serum levels of VEGF, bFGF, IL-1β and TNF-α by ELISA in patients with inflammatory pericardial effusion (PE) of autoreactive (n=22) and viral (n=11) origin, and for control in pericardial fluid (PF) and serum (n=26) of patients with coronary artery disease (CAD) undergoing coronary artery bypass graft surgery.
Results.
VEGF levels were significantly higher in patients with autoreactive and viral PE than in patients with CAD in both PE (P=0,006 for autoreactive and P<0,001 for viral PE) and serum (P<0,001 for autoreactive and P<0,001 for viral PE).
Pericardial bFGF levels were higher compared to serum levels in patients with inflammatory PE and patients with CAD (P≤0,001 for CAD; P≤0,001 for autoreactive PE; P=0,005 for viral PE).
Pericardial VEGF levels correlated positively with markers of pericardial inflammation, whereas pericardial bFGF levels showed a negative correlation.
IL-1β and TNF-α were detectable only in few PE and serum samples.
Conclusions.
VEGF and bFGF levels in pericardial effusion are elevated in patients with inflammatory PE.
It is thus possible that VEGF and bFGF participate in the pathogenesis of inflammatory pericardial disease.
American Psychological Association (APA)
Karatolios, Konstantinos& Moosdorf, Rainer& Maisch, Bernhard& Pankuweit, Sabine. 2012. Cytokines in Pericardial Effusion of Patients with Inflammatory Pericardial Disease. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-998886
Modern Language Association (MLA)
Karatolios, Konstantinos…[et al.]. Cytokines in Pericardial Effusion of Patients with Inflammatory Pericardial Disease. Mediators of Inflammation No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-998886
American Medical Association (AMA)
Karatolios, Konstantinos& Moosdorf, Rainer& Maisch, Bernhard& Pankuweit, Sabine. Cytokines in Pericardial Effusion of Patients with Inflammatory Pericardial Disease. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-998886
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998886