Thrombopoietin as Biomarker and Mediator of Cardiovascular Damage in Critical Diseases
Joint Authors
Lupia, Enrico
Goffi, Alberto
Bosco, Ornella
Montrucchio, Giuseppe
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Thrombopoietin (TPO) is a humoral growth factor originally identified for its ability to stimulate the proliferation and differentiation of megakaryocytes.
In addition to its actions on thrombopoiesis, TPO directly modulates the homeostatic potential of mature platelets by influencing their response to several stimuli.
In particular, TPO does not induce platelet aggregation per se but is able to enhance platelet aggregation in response to different agonists (“priming effect”).
Our research group was actively involved, in the last years, in characterizing the effects of TPO in several human critical diseases.
In particular, we found that TPO enhances platelet activation and monocyte-platelet interaction in patients with unstable angina, chronic cigarette smokers, and patients with burn injury and burn injury complicated with sepsis.
Moreover, we showed that TPO negatively modulates myocardial contractility by stimulating its receptor c-Mpl on cardiomyocytes and the subsequent production of NO, and it mediates the cardiodepressant activity exerted in vitro by serum of septic shock patients by cooperating with TNF-α and IL-1β.
This paper will summarize the most recent results obtained by our research group on the pathogenic role of elevated TPO levels in these diseases and discuss them together with other recently published important studies on this topic.
American Psychological Association (APA)
Lupia, Enrico& Goffi, Alberto& Bosco, Ornella& Montrucchio, Giuseppe. 2012. Thrombopoietin as Biomarker and Mediator of Cardiovascular Damage in Critical Diseases. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-998889
Modern Language Association (MLA)
Lupia, Enrico…[et al.]. Thrombopoietin as Biomarker and Mediator of Cardiovascular Damage in Critical Diseases. Mediators of Inflammation No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-998889
American Medical Association (AMA)
Lupia, Enrico& Goffi, Alberto& Bosco, Ornella& Montrucchio, Giuseppe. Thrombopoietin as Biomarker and Mediator of Cardiovascular Damage in Critical Diseases. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-998889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998889