Association between Serum Neopterin and Inflammatory Activation in Chronic Kidney Disease
Joint Authors
Jha, Vivekanand
Yadav, Ashok K.
Kumar, Vinod
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The serum levels of neopterin, a marker associated with cell-mediated immunity are elevated in chronic kidney disease (CKD).
We evaluated serum neopterin levels and investigated its association with markers of inflammation in a cross-section of CKD subjects without known cardiovascular disease.
Methods.
Serum neopterin levels were measured in 118 patients with stage 3–5 CKD and 41 healthy subjects with normal kidney function (HC).
Patients with known cardiovascular disease were excluded.
We also estimated highly sensitive CRP (hsCRP) and interluekin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in the CKD subjects.
All assays were done using commercially available ELISA kits.
The correlation between neopterin and markers of inflammation were investigated.
Results.
Of the CKD population, 82 were in stage 5 (60 stage 5 D), 24 in stage 4, and 12 in stage 3.
The mean age was 51.04±1.3 years and 66% were males.
The commonest cause of CKD was diabetes (36%).
Serum neopterin levels were 5-fold higher in CKD patients as compared to HC (74.8±3.6 versus 15.0±2.8 nmol/L, P<0.0001).
There was a graded increase of serum neopterin from stages 3 to 4 and 5.
CKD 5 D patients exhibited significantly higher levels compared to nondialysis stage 5 patients (P<0.0001).
An inverse correlation was noted between serum neopterin and eGFR (r=−0.359, P<0.0001).
Serum neopterin correlated with hsCRP (r=0.285, P=0.002), IL-6 (r=0.212, P=0.034), and IFN-γ (r=0.32, P=0.001) but not with TNF-α.
Conclusion.
Serum neopterin level is elevated and correlates with the severity of CKD.
The elevation correlates with elevation of most, but not all, inflammatory markers.
Its role in future development of cardiovascular disease and modulation with anti-inflammatory therapies needs further studies.
American Psychological Association (APA)
Yadav, Ashok K.& Kumar, Vinod& Jha, Vivekanand. 2012. Association between Serum Neopterin and Inflammatory Activation in Chronic Kidney Disease. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-998976
Modern Language Association (MLA)
Yadav, Ashok K.…[et al.]. Association between Serum Neopterin and Inflammatory Activation in Chronic Kidney Disease. Mediators of Inflammation No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-998976
American Medical Association (AMA)
Yadav, Ashok K.& Kumar, Vinod& Jha, Vivekanand. Association between Serum Neopterin and Inflammatory Activation in Chronic Kidney Disease. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-998976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998976