Lipid Bodies: Inflammatory Organelles Implicated in Host-Trypanosoma cruzi Interplay during Innate Immune Responses
Joint Authors
D'Avila, Heloisa
Toledo, Daniel A. M.
Melo, Rossana C. N.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The flagellated protozoa Trypanosoma cruzi is the causal agent of Chagas' disease, a significant public health issue and still a major cause of morbidity and mortality in Latin America.
Acute Chagas' disease elicits a strong inflammatory response.
In order to control the parasite multiplication, cells of the monocytic lineage are highly mobilized.
Monocyte differentiation leads to the formation of phagocytosing macrophages, which are strongly activated and direct host defense.
A distinguishing feature of Chagas' disease-triggered macrophages is the presence of increased numbers of distinct cytoplasmic organelles termed lipid bodies or lipid droplets.
These organelles are actively formed in response to the parasite and are sites for synthesis and storage of inflammatory mediators.
This review covers current knowledge on lipid bodies elicited by the acute Chagas' disease within inflammatory macrophages and discusses the role of these organelles in inflammation.
The increased knowledge of lipid bodies in pathogenic mechanisms of infections may not only contribute to the understanding of pathogen-host interactions but may also identify new targets for intervention.
American Psychological Association (APA)
D'Avila, Heloisa& Toledo, Daniel A. M.& Melo, Rossana C. N.. 2012. Lipid Bodies: Inflammatory Organelles Implicated in Host-Trypanosoma cruzi Interplay during Innate Immune Responses. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-998982
Modern Language Association (MLA)
D'Avila, Heloisa…[et al.]. Lipid Bodies: Inflammatory Organelles Implicated in Host-Trypanosoma cruzi Interplay during Innate Immune Responses. Mediators of Inflammation No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-998982
American Medical Association (AMA)
D'Avila, Heloisa& Toledo, Daniel A. M.& Melo, Rossana C. N.. Lipid Bodies: Inflammatory Organelles Implicated in Host-Trypanosoma cruzi Interplay during Innate Immune Responses. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-998982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998982