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Pathophysiological Changes to the Peritoneal Membrane during PD-Related Peritonitis: The Role of Mesothelial Cells
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-10
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
The success of peritoneal dialysis (PD) is dependent on the structural and functional integrity of the peritoneal membrane.
The mesothelium lines the peritoneal membrane and is the first line of defense against chemical and/or bacterial insult.
Peritonitis remains a major complication of PD and is a predominant cause of technique failure, morbidity and mortality amongst PD patients.
With appropriate antibiotic treatment, peritonitis resolves without further complications, but in some PD patients excessive peritoneal inflammatory responses lead to mesothelial cell exfoliation and thickening of the submesothelium, resulting in peritoneal fibrosis and sclerosis.
The detrimental changes in the peritoneal membrane structure and function correlate with the number and severity of peritonitis episodes and the need for catheter removal.
There is evidence that despite clinical resolution of peritonitis, increased levels of inflammatory and fibrotic mediators may persist in the peritoneal cavity, signifying persistent injury to the mesothelial cells.
This review will describe the structural and functional changes that occur in the peritoneal membrane during peritonitis and how mesothelial cells contribute to these changes and respond to infection.
The latter part of the review discusses the potential of mesothelial cell transplantation and genetic manipulation in the preservation of the peritoneal membrane.
American Psychological Association (APA)
Yung, Susan& Chan, Tak Mao. 2012. Pathophysiological Changes to the Peritoneal Membrane during PD-Related Peritonitis: The Role of Mesothelial Cells. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-998983
Modern Language Association (MLA)
Yung, Susan& Chan, Tak Mao. Pathophysiological Changes to the Peritoneal Membrane during PD-Related Peritonitis: The Role of Mesothelial Cells. Mediators of Inflammation No. 2012 (2012), pp.1-21.
https://search.emarefa.net/detail/BIM-998983
American Medical Association (AMA)
Yung, Susan& Chan, Tak Mao. Pathophysiological Changes to the Peritoneal Membrane during PD-Related Peritonitis: The Role of Mesothelial Cells. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-998983
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998983