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Cytogenetic analyses of the anti-mutagenic effect of tamarix nilotica in mice bone marrow
Other Title(s)
التحليل الوراثي السيتولوجي للتأثير المضاد للطفور لنبات الأثل النيلي في نخاع عظام فئران المعمل الصغيرة
Joint Authors
Abd al-Tawwab, Fathi Muhammad
al-Sanusi, Nimah Qutub
Shibl, Shayma Ahmad
Abdu, Halimah Sayyid
Hassanin, Mahrusah Muhammad
Darwish, Hasan Ramadan
Source
Arab Universities Journal of Agricultural Sciences
Issue
Vol. 27, Issue 3 (31 Jul. 2019), pp.1909-1917, 9 p.
Publisher
Ain Shams University Faculty of Agriculture
Publication Date
2019-07-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Topics
- Digestive system
- Bone marrow
- Medicinal plants
- Traditional medicine
- Phenols
- Chromosome abnormalities
- Mitomycin C
Abstract EN
The usages of medicinal plants as therapeutic agents have been practiced in a large scale of applications that make studies of their mutagenicity and/or anti-mutagenic /anti-carcinogenic effects very essential.
The current investigation is focused on the anti-mutagenic effects of the Tamarix nilotica (Ehrenb) crude extract using chromosomal aberrations analysis in mice bone marrow.
In fact, a single plant may have diversity of phytochemicals ranging from bitter compounds that stimulate digestive system, phenolic compounds for antioxidants and many other pharmacological properties, antibacterial, and antifungal, tannins that work as natural antibiotics, diuretic substances and alkaloids, etc.
Tamarix is represented in Egypt with two indigenous species which are Tamarix aphylla (L.
) (H.
Karst) and T.
nilotica (Ehrenb.
) Bunge (T.
nilotica (Ehrenb.
).
In addition, it was used in Egyptian traditional medicine as an antiseptic agent.
Extracts of Tamarix species have been widely used in traditional medicine in Asia and Africa mainly for their antiseptic, astringent, diaphoretic and diuretic properties.
The current investigation is focused on the anti-mutagenic effects of the Tamarix nilotica crude extract using chromosomal aberrations analysis in mice bone marrow.
Mitomycin C (MMC) was administered to mice as a positive control alone before and after treatment with 5 or 0.5 mg/ kg b.
wt Tamarix crude extract as acute (24 and 48 h) and sub-acute (15 consecutive days) doses respectively.
Results indicated that the Mitomycin C (MMC) exposure induced statistically significant increase in chromosomal aberrations compared to the control, however T.
nilotica revealed slight insignificant effect on aberrant mitosis rate.
Chromosomal aberration domain structural and numerical aberrations.
The frequency of chromosomal aberrations (CA) and mitotic index (MI) decreased with increasing the dose and time of T.
nilotica treatment, especially pre-treatment (plant + MMC).
This effect was found to be dose-dependent.
In conclusion, the results showed that T.
nilotica could be considered as a good anti-mutagenic agent.
American Psychological Association (APA)
Shibl, Shayma Ahmad& Abd al-Tawwab, Fathi Muhammad& Abdu, Halimah Sayyid& al-Sanusi, Nimah Qutub& Hassanin, Mahrusah Muhammad& Darwish, Hasan Ramadan. 2019. Cytogenetic analyses of the anti-mutagenic effect of tamarix nilotica in mice bone marrow. Arab Universities Journal of Agricultural Sciences،Vol. 27, no. 3, pp.1909-1917.
https://search.emarefa.net/detail/BIM-999997
Modern Language Association (MLA)
Shibl, Shayma Ahmad…[et al.]. Cytogenetic analyses of the anti-mutagenic effect of tamarix nilotica in mice bone marrow. Arab Universities Journal of Agricultural Sciences Vol. 27, no. 3 (2019), pp.1909-1917.
https://search.emarefa.net/detail/BIM-999997
American Medical Association (AMA)
Shibl, Shayma Ahmad& Abd al-Tawwab, Fathi Muhammad& Abdu, Halimah Sayyid& al-Sanusi, Nimah Qutub& Hassanin, Mahrusah Muhammad& Darwish, Hasan Ramadan. Cytogenetic analyses of the anti-mutagenic effect of tamarix nilotica in mice bone marrow. Arab Universities Journal of Agricultural Sciences. 2019. Vol. 27, no. 3, pp.1909-1917.
https://search.emarefa.net/detail/BIM-999997
Data Type
Journal Articles
Language
English
Notes
-
Record ID
BIM-999997