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Osteopontin and Other Regulators of Angiogenesis and Fibrogenesis in the Vitreous from Patients with Proliferative Vitreoretinal Disorders
المؤلفون المشاركون
Geboes, Karel
Abu El-Asrar, Ahmed M.
Nawaz, Mohd Imtiaz
Kangave, Dustan
Siddiquei, Mohammad Mairaj
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The aim of this study was to determine the levels of the angiogenic and fibrogenic factors osteopontin (OPN), high-mobility group box-1 (HMGB1), and connective tissue growth factor (CTGF) and the antiangiogenic and antifibrogenic pigment epithelium-derived factor (PEDF) in the vitreous fluid from patients with proliferative diabetic retinopathy (PDR), proliferative vitreoretinopathy (PVR), and rhegmatogenous retinal detachment with no PVR (RD).
Vitreous samples from 48 PDR, 17 PVR and 30 RD patients were studied by enzyme-linked immunosorbent assay.
OPN, HMGB1, CTGF, and PEDF levels were significantly higher in PDR patients than in RD patients (P<0.001; 0.002; <0.001; <0.001, resp.).
CTGF and PEDF levels were significantly higher in PVR patients than in RD patients (P<0.001;0.004, resp.).
Exploratory logistic regression analysis identified significant associations between PDR and high levels of HMGB1, CTGF and PEDF, between PDR with active neovascularization and high levels of CTGF and PEDF, and between PDR with traction retinal detachment and high levels of HMGB1.
In patients with PDR, there were significant correlations between the levels of PEDF and the levels of OPN (r=0.544,P=0.001), HMGB1 (r=0.719,P<0.001), and CTGF (r=0.715,P<0.001).
In patients with PVR, there were significant correlations between the levels of OPN and the levels of HMGB1 (r=0.484,P=0.049) and PEDF (r=0.559,P=0.02).
Our findings suggest that OPN, HMGB1, and CTGF contribute to the pathogenesis of proliferative vitreoretinal disorders and that increased levels of PEDF may be a response to counterbalance the activity of angiogenic and fibrogenic factors in PDR and PVR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abu El-Asrar, Ahmed M.& Nawaz, Mohd Imtiaz& Kangave, Dustan& Siddiquei, Mohammad Mairaj& Geboes, Karel. 2012. Osteopontin and Other Regulators of Angiogenesis and Fibrogenesis in the Vitreous from Patients with Proliferative Vitreoretinal Disorders. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1001156
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abu El-Asrar, Ahmed M.…[et al.]. Osteopontin and Other Regulators of Angiogenesis and Fibrogenesis in the Vitreous from Patients with Proliferative Vitreoretinal Disorders. Mediators of Inflammation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1001156
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abu El-Asrar, Ahmed M.& Nawaz, Mohd Imtiaz& Kangave, Dustan& Siddiquei, Mohammad Mairaj& Geboes, Karel. Osteopontin and Other Regulators of Angiogenesis and Fibrogenesis in the Vitreous from Patients with Proliferative Vitreoretinal Disorders. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1001156
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1001156
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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