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Role of Macrophage Migration Inhibitory Factor in the Proliferation of Smooth Muscle Cell in Pulmonary Hypertension
المؤلفون المشاركون
Zhang, Bo
Shen, Min
Xu, Min
Liu, Li-Li
Luo, Ying
Xu, Dun-Quan
Wang, Yan-Xia
Liu, Man-Ling
Liu, Yi
Dong, Hai-Ying
Zhao, Peng-Tao
Li, Zhi-Chao
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-01-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Pulmonary hypertension (PH) contributes to the mortality of patients with lung and heart diseases.
However, the underlying mechanism has not been completely elucidated.
Accumulating evidence suggests that inflammatory response may be involved in the pathogenesis of PH.
Macrophage migration inhibitory factor (MIF) is a critical upstream inflammatory mediator which promotes a broad range of pathophysiological processes.
The aim of the study was to investigate the role of MIF in the pulmonary vascular remodeling of hypoxia-induced PH.
We found that MIF mRNA and protein expression was increased in the lung tissues from hypoxic pulmonary hypertensive rats.
Intensive immunoreactivity for MIF was observed in smooth muscle cells of large pulmonary arteries (PAs), endothelial cells of small PAs, and inflammatory cells of hypoxic lungs.
MIF participated in the hypoxia-induced PASMCs proliferation, and it could directly stimulate proliferation of these cells.
MIF-induced enhanced growth of PASMCs was attenuated by MEK and JNK inhibitor.
Besides, MIF antagonist ISO-1 suppressed the ERK1/2 and JNK phosphorylation induced by MIF.
In conclusion, the current finding suggested that MIF may act on the proliferation of PASMCs through the activation of the ERK1/2 and JNK pathways, which contributes to hypoxic pulmonary hypertension.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Bo& Shen, Min& Xu, Min& Liu, Li-Li& Luo, Ying& Xu, Dun-Quan…[et al.]. 2012. Role of Macrophage Migration Inhibitory Factor in the Proliferation of Smooth Muscle Cell in Pulmonary Hypertension. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1001239
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Bo…[et al.]. Role of Macrophage Migration Inhibitory Factor in the Proliferation of Smooth Muscle Cell in Pulmonary Hypertension. Mediators of Inflammation No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1001239
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Bo& Shen, Min& Xu, Min& Liu, Li-Li& Luo, Ying& Xu, Dun-Quan…[et al.]. Role of Macrophage Migration Inhibitory Factor in the Proliferation of Smooth Muscle Cell in Pulmonary Hypertension. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1001239
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1001239
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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