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Role of Macrophage Migration Inhibitory Factor in the Proliferation of Smooth Muscle Cell in Pulmonary Hypertension
Joint Authors
Zhang, Bo
Shen, Min
Xu, Min
Liu, Li-Li
Luo, Ying
Xu, Dun-Quan
Wang, Yan-Xia
Liu, Man-Ling
Liu, Yi
Dong, Hai-Ying
Zhao, Peng-Tao
Li, Zhi-Chao
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Pulmonary hypertension (PH) contributes to the mortality of patients with lung and heart diseases.
However, the underlying mechanism has not been completely elucidated.
Accumulating evidence suggests that inflammatory response may be involved in the pathogenesis of PH.
Macrophage migration inhibitory factor (MIF) is a critical upstream inflammatory mediator which promotes a broad range of pathophysiological processes.
The aim of the study was to investigate the role of MIF in the pulmonary vascular remodeling of hypoxia-induced PH.
We found that MIF mRNA and protein expression was increased in the lung tissues from hypoxic pulmonary hypertensive rats.
Intensive immunoreactivity for MIF was observed in smooth muscle cells of large pulmonary arteries (PAs), endothelial cells of small PAs, and inflammatory cells of hypoxic lungs.
MIF participated in the hypoxia-induced PASMCs proliferation, and it could directly stimulate proliferation of these cells.
MIF-induced enhanced growth of PASMCs was attenuated by MEK and JNK inhibitor.
Besides, MIF antagonist ISO-1 suppressed the ERK1/2 and JNK phosphorylation induced by MIF.
In conclusion, the current finding suggested that MIF may act on the proliferation of PASMCs through the activation of the ERK1/2 and JNK pathways, which contributes to hypoxic pulmonary hypertension.
American Psychological Association (APA)
Zhang, Bo& Shen, Min& Xu, Min& Liu, Li-Li& Luo, Ying& Xu, Dun-Quan…[et al.]. 2012. Role of Macrophage Migration Inhibitory Factor in the Proliferation of Smooth Muscle Cell in Pulmonary Hypertension. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1001239
Modern Language Association (MLA)
Zhang, Bo…[et al.]. Role of Macrophage Migration Inhibitory Factor in the Proliferation of Smooth Muscle Cell in Pulmonary Hypertension. Mediators of Inflammation No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1001239
American Medical Association (AMA)
Zhang, Bo& Shen, Min& Xu, Min& Liu, Li-Li& Luo, Ying& Xu, Dun-Quan…[et al.]. Role of Macrophage Migration Inhibitory Factor in the Proliferation of Smooth Muscle Cell in Pulmonary Hypertension. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1001239
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001239