Update on Transanal NOTES for Rectal Cancer: Transitioning to Human Trials

الملخص EN

The feasibility of natural orifice translumenal endoscopic surgery (NOTES) resection for rectal cancer has been demonstrated in both survival swine and fresh human cadaveric models.

In preparation for transitioning to human application, our group has performed transanal NOTES rectal resection in a large series of human cadavers.

This experience both solidified the feasibility of resection and allowed optimization of technique prior to clinical application.

Improvement in specimen length and operative time was demonstrated with increased experience and newer platforms.

This extensive laboratory experience has paved the way for successful clinical translation resulting in an ongoing clinical trial.

To date, based on published reports, 4 human subjects have undergone successful hybrid transanal NOTES resection of rectal cancer.

While promising, instrument limitations continue to hinder a pure transanal approach.

Careful patient selection and continued development of new endoscopic and flexible-tip instruments are imperative prior to pure NOTES clinical application.