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Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities
المؤلفون المشاركون
Rueda, Noemí
Flórez, Jesús
Martínez-Cué, Carmen
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-26، 26ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-08
دولة النشر
مصر
عدد الصفحات
26
التخصصات الرئيسية
الملخص EN
Down syndrome (DS) is the most common genetic cause of mental disability.
Based on the homology of Hsa21 and the murine chromosomes Mmu16, Mmu17 and Mmu10, several mouse models of DS have been developed.
The most commonly used model, the Ts65Dn mouse, has been widely used to investigate the neural mechanisms underlying the mental disabilities seen in DS individuals.
A wide array of neuromorphological alterations appears to compromise cognitive performance in trisomic mice.
Enhanced inhibition due to alterations in GABAA-mediated transmission and disturbances in the glutamatergic, noradrenergic and cholinergic systems, among others, has also been demonstrated.
DS cognitive dysfunction caused by neurodevelopmental alterations is worsened in later life stages by neurodegenerative processes.
A number of pharmacological therapies have been shown to partially restore morphological anomalies concomitantly with cognition in these mice.
In conclusion, the use of mouse models is enormously effective in the study of the neurobiological substrates of mental disabilities in DS and in the testing of therapies that rescue these alterations.
These studies provide the basis for developing clinical trials in DS individuals and sustain the hope that some of these drugs will be useful in rescuing mental disabilities in DS individuals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rueda, Noemí& Flórez, Jesús& Martínez-Cué, Carmen. 2012. Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities. Neural Plasticity،Vol. 2012, no. 2012, pp.1-26.
https://search.emarefa.net/detail/BIM-1002436
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rueda, Noemí…[et al.]. Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities. Neural Plasticity No. 2012 (2012), pp.1-26.
https://search.emarefa.net/detail/BIM-1002436
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rueda, Noemí& Flórez, Jesús& Martínez-Cué, Carmen. Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-26.
https://search.emarefa.net/detail/BIM-1002436
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1002436
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