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Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities
Joint Authors
Rueda, Noemí
Flórez, Jesús
Martínez-Cué, Carmen
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-26, 26 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-08
Country of Publication
Egypt
No. of Pages
26
Main Subjects
Abstract EN
Down syndrome (DS) is the most common genetic cause of mental disability.
Based on the homology of Hsa21 and the murine chromosomes Mmu16, Mmu17 and Mmu10, several mouse models of DS have been developed.
The most commonly used model, the Ts65Dn mouse, has been widely used to investigate the neural mechanisms underlying the mental disabilities seen in DS individuals.
A wide array of neuromorphological alterations appears to compromise cognitive performance in trisomic mice.
Enhanced inhibition due to alterations in GABAA-mediated transmission and disturbances in the glutamatergic, noradrenergic and cholinergic systems, among others, has also been demonstrated.
DS cognitive dysfunction caused by neurodevelopmental alterations is worsened in later life stages by neurodegenerative processes.
A number of pharmacological therapies have been shown to partially restore morphological anomalies concomitantly with cognition in these mice.
In conclusion, the use of mouse models is enormously effective in the study of the neurobiological substrates of mental disabilities in DS and in the testing of therapies that rescue these alterations.
These studies provide the basis for developing clinical trials in DS individuals and sustain the hope that some of these drugs will be useful in rescuing mental disabilities in DS individuals.
American Psychological Association (APA)
Rueda, Noemí& Flórez, Jesús& Martínez-Cué, Carmen. 2012. Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities. Neural Plasticity،Vol. 2012, no. 2012, pp.1-26.
https://search.emarefa.net/detail/BIM-1002436
Modern Language Association (MLA)
Rueda, Noemí…[et al.]. Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities. Neural Plasticity No. 2012 (2012), pp.1-26.
https://search.emarefa.net/detail/BIM-1002436
American Medical Association (AMA)
Rueda, Noemí& Flórez, Jesús& Martínez-Cué, Carmen. Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-26.
https://search.emarefa.net/detail/BIM-1002436
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002436