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Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies
المؤلفون المشاركون
Takenouchi, Takato
Sekiyama, Kazunari
Takamatsu, Yoshiki
Fujita, Masayo
Hashimoto, Makoto
Waragai, Masaaki
Sugama, Shuei
Sekigawa, Akio
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-25
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Neuroinflammation in Parkinson's disease (PD) is a chronic process that is associated with alteration of glial cells, including astrocytes and microglia.
However, the precise mechanisms remain obscure.
To better understand neuroinflammation in PD, we focused on glial activation in α-synuclein (αS) transgenic and related model mice.
In the majority of αS transgenic mice, astrogliosis was observed concomitantly with accumulation of αS during the early stage of neurodegeneration.
However, microglia were not extensively activated unless the mice were treated with lipopolysaccharides or through further genetic modification of other molecules, including familial PD risk factors.
Thus, the results in αS transgenic mice and related model mice are consistent with the idea that neuroinflammation in PD is a double-edged sword that is protective in the early stage of neurodegeneration but becomes detrimental with disease progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sekiyama, Kazunari& Sugama, Shuei& Fujita, Masayo& Sekigawa, Akio& Takamatsu, Yoshiki& Waragai, Masaaki…[et al.]. 2012. Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies. Parkinson’s Disease،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002764
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sekiyama, Kazunari…[et al.]. Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies. Parkinson’s Disease No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1002764
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sekiyama, Kazunari& Sugama, Shuei& Fujita, Masayo& Sekigawa, Akio& Takamatsu, Yoshiki& Waragai, Masaaki…[et al.]. Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies. Parkinson’s Disease. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002764
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1002764
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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