Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies
Joint Authors
Takenouchi, Takato
Sekiyama, Kazunari
Takamatsu, Yoshiki
Fujita, Masayo
Hashimoto, Makoto
Waragai, Masaaki
Sugama, Shuei
Sekigawa, Akio
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Neuroinflammation in Parkinson's disease (PD) is a chronic process that is associated with alteration of glial cells, including astrocytes and microglia.
However, the precise mechanisms remain obscure.
To better understand neuroinflammation in PD, we focused on glial activation in α-synuclein (αS) transgenic and related model mice.
In the majority of αS transgenic mice, astrogliosis was observed concomitantly with accumulation of αS during the early stage of neurodegeneration.
However, microglia were not extensively activated unless the mice were treated with lipopolysaccharides or through further genetic modification of other molecules, including familial PD risk factors.
Thus, the results in αS transgenic mice and related model mice are consistent with the idea that neuroinflammation in PD is a double-edged sword that is protective in the early stage of neurodegeneration but becomes detrimental with disease progression.
American Psychological Association (APA)
Sekiyama, Kazunari& Sugama, Shuei& Fujita, Masayo& Sekigawa, Akio& Takamatsu, Yoshiki& Waragai, Masaaki…[et al.]. 2012. Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies. Parkinson’s Disease،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002764
Modern Language Association (MLA)
Sekiyama, Kazunari…[et al.]. Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies. Parkinson’s Disease No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1002764
American Medical Association (AMA)
Sekiyama, Kazunari& Sugama, Shuei& Fujita, Masayo& Sekigawa, Akio& Takamatsu, Yoshiki& Waragai, Masaaki…[et al.]. Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies. Parkinson’s Disease. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002764
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002764