Antioxidant Potential of a Polyherbal Antimalarial as an Indicator of Its Therapeutic Value

المؤلفون المشاركون

Nwachiban Atchan, Achille Parfait
Guantai, Anastasia Nkatha
Kuiate, Jules-Roger
Arrey Tarkang, Protus
Agbor, Gabriel Agbor
Okalebo, Faith Apoelot

المصدر

Advances in Pharmacological and Pharmaceutical Sciences

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-12-19

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

علم الصيدلة

الملخص EN

Nefang is a polyherbal product composed of Mangifera indica (bark and leaf), Psidium guajava, Carica papaya, Cymbopogon citratus, Citrus sinensis, and Ocimum gratissimum (leaves), used for the treatment of malaria.

Compounds with antioxidant activity are believed to modulate plasmodial infection.

Antioxidant activity of the constituent aqueous plants extracts, in vitro, was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH), total phenolic content (TPC), and ferric reducing antioxidant power (FRAP) methods and, in vivo, Nefang (100 and 500 mg kg−1) activity was evaluated in carbon tetrachloride-induced oxidative stressed Wistar rats.

Superoxide dismutase, catalase activities, and lipid peroxidation by the malondialdehyde and total proteins assays were carried out.

P.

guajava, M.

indica leaf, and bark extracts had the highest antioxidant properties in all three assays, with no statistically significant difference.

Rats treated with the carbon tetrachloride had a statistically significant decrease in levels of triglycerides, superoxide dismutase, and catalase (P<0.05) and increase in malondialdehyde activity, total protein levels, and liver and renal function markers, whereas rats treated with Nefang showed increased levels in the former and dose-dependent decrease towards normal levels in the later.

These results reveal the constituent plants of Nefang that contribute to its in vivo antioxidant potential.

This activity is a good indication of the therapeutic potential of Nefang.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Arrey Tarkang, Protus& Nwachiban Atchan, Achille Parfait& Kuiate, Jules-Roger& Okalebo, Faith Apoelot& Guantai, Anastasia Nkatha& Agbor, Gabriel Agbor. 2013. Antioxidant Potential of a Polyherbal Antimalarial as an Indicator of Its Therapeutic Value. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003216

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Arrey Tarkang, Protus…[et al.]. Antioxidant Potential of a Polyherbal Antimalarial as an Indicator of Its Therapeutic Value. Advances in Pharmacological and Pharmaceutical Sciences No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1003216

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Arrey Tarkang, Protus& Nwachiban Atchan, Achille Parfait& Kuiate, Jules-Roger& Okalebo, Faith Apoelot& Guantai, Anastasia Nkatha& Agbor, Gabriel Agbor. Antioxidant Potential of a Polyherbal Antimalarial as an Indicator of Its Therapeutic Value. Advances in Pharmacological and Pharmaceutical Sciences. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003216

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1003216