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Antioxidant Potential of a Polyherbal Antimalarial as an Indicator of Its Therapeutic Value
Joint Authors
Nwachiban Atchan, Achille Parfait
Guantai, Anastasia Nkatha
Kuiate, Jules-Roger
Arrey Tarkang, Protus
Agbor, Gabriel Agbor
Okalebo, Faith Apoelot
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nefang is a polyherbal product composed of Mangifera indica (bark and leaf), Psidium guajava, Carica papaya, Cymbopogon citratus, Citrus sinensis, and Ocimum gratissimum (leaves), used for the treatment of malaria.
Compounds with antioxidant activity are believed to modulate plasmodial infection.
Antioxidant activity of the constituent aqueous plants extracts, in vitro, was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH), total phenolic content (TPC), and ferric reducing antioxidant power (FRAP) methods and, in vivo, Nefang (100 and 500 mg kg−1) activity was evaluated in carbon tetrachloride-induced oxidative stressed Wistar rats.
Superoxide dismutase, catalase activities, and lipid peroxidation by the malondialdehyde and total proteins assays were carried out.
P.
guajava, M.
indica leaf, and bark extracts had the highest antioxidant properties in all three assays, with no statistically significant difference.
Rats treated with the carbon tetrachloride had a statistically significant decrease in levels of triglycerides, superoxide dismutase, and catalase (P<0.05) and increase in malondialdehyde activity, total protein levels, and liver and renal function markers, whereas rats treated with Nefang showed increased levels in the former and dose-dependent decrease towards normal levels in the later.
These results reveal the constituent plants of Nefang that contribute to its in vivo antioxidant potential.
This activity is a good indication of the therapeutic potential of Nefang.
American Psychological Association (APA)
Arrey Tarkang, Protus& Nwachiban Atchan, Achille Parfait& Kuiate, Jules-Roger& Okalebo, Faith Apoelot& Guantai, Anastasia Nkatha& Agbor, Gabriel Agbor. 2013. Antioxidant Potential of a Polyherbal Antimalarial as an Indicator of Its Therapeutic Value. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003216
Modern Language Association (MLA)
Arrey Tarkang, Protus…[et al.]. Antioxidant Potential of a Polyherbal Antimalarial as an Indicator of Its Therapeutic Value. Advances in Pharmacological and Pharmaceutical Sciences No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1003216
American Medical Association (AMA)
Arrey Tarkang, Protus& Nwachiban Atchan, Achille Parfait& Kuiate, Jules-Roger& Okalebo, Faith Apoelot& Guantai, Anastasia Nkatha& Agbor, Gabriel Agbor. Antioxidant Potential of a Polyherbal Antimalarial as an Indicator of Its Therapeutic Value. Advances in Pharmacological and Pharmaceutical Sciences. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003216
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003216