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Regulation of Tissue Fibrosis by the Biomechanical Environment
المؤلفون المشاركون
Carver, Wayne
Goldsmith, Edie C.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The biomechanical environment plays a fundamental role in embryonic development, tissue maintenance, and pathogenesis.
Mechanical forces play particularly important roles in the regulation of connective tissues including not only bone and cartilage but also the interstitial tissues of most organs.
In vivo studies have correlated changes in mechanical load to modulation of the extracellular matrix and have indicated that increased mechanical force contributes to the enhanced expression and deposition of extracellular matrix components or fibrosis.
Pathological fibrosis contributes to dysfunction of many organ systems.
A variety of in vitro models have been utilized to evaluate the effects of mechanical force on extracellular matrix-producing cells.
In general, application of mechanical stretch, fluid flow, and compression results in increased expression of extracellular matrix components.
More recent studies have indicated that tissue rigidity also provides profibrotic signals to cells.
The mechanisms whereby cells detect mechanical signals and transduce them into biochemical responses have received considerable attention.
Cell surface receptors for extracellular matrix components and intracellular signaling pathways are instrumental in the mechanotransduction process.
Understanding how mechanical signals are transmitted from the microenvironment will identify novel therapeutic targets for fibrosis and other pathological conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Carver, Wayne& Goldsmith, Edie C.. 2013. Regulation of Tissue Fibrosis by the Biomechanical Environment. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1003248
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Carver, Wayne& Goldsmith, Edie C.. Regulation of Tissue Fibrosis by the Biomechanical Environment. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1003248
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Carver, Wayne& Goldsmith, Edie C.. Regulation of Tissue Fibrosis by the Biomechanical Environment. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1003248
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1003248
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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